FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2757081551> ?p ?o ?g. }

• W2757081551 endingPage "2537" @default.
• W2757081551 startingPage "2530" @default.
• W2757081551 abstract "Although aptamers are well-known as cell-specific membrane biomarkers for tumor-targeted therapy, it is important to avoid their degradation by nucleases in vivo. In this study, we developed a MUC1 aptamer-doxorubicin nanoconjugate (APT-DOX) through an acid-labile linkage and embedded APT-DOX into a thermosensitive hydrogel for antitumor therapy. The hydrogels exhibit a sol-gel transition upon intratumoral injection, resulting in the protection and controlled release control of APT-DOX with the shielding of the gel network. Moreover, the released APT-DOX was prone to be enriched at the tumor cells due to specific intracellular transport by the overexpressing MUC1 protein; however, APT-DOX regained the free DOX form via the rupture of the linkage under tumor cells lysosome acidic conditions and achieved increased concentration in the nucleus for antitumor treatment." @default.
• W2757081551 created "2017-10-06" @default.
• W2757081551 creator A5000519808 @default.
• W2757081551 creator A5029881551 @default.
• W2757081551 creator A5036401376 @default.
• W2757081551 creator A5060312536 @default.
• W2757081551 creator A5063750534 @default.
• W2757081551 creator A5067138179 @default.
• W2757081551 creator A5075423250 @default.
• W2757081551 date "2017-10-05" @default.
• W2757081551 modified "2023-10-16" @default.
• W2757081551 title "Microenvironmental Control of MUC1 Aptamer-Guided Acid-Labile Nanoconjugate within Injectable Microporous Hydrogels" @default.
• W2757081551 cites W1584842088 @default.
• W2757081551 cites W1964056042 @default.
• W2757081551 cites W1964766613 @default.
• W2757081551 cites W1965552267 @default.
• W2757081551 cites W1980183609 @default.
• W2757081551 cites W1986107627 @default.
• W2757081551 cites W1992374132 @default.
• W2757081551 cites W1997353385 @default.
• W2757081551 cites W1997686479 @default.
• W2757081551 cites W2009911359 @default.
• W2757081551 cites W2009999352 @default.
• W2757081551 cites W2017296058 @default.
• W2757081551 cites W2046802601 @default.
• W2757081551 cites W2055713782 @default.
• W2757081551 cites W2058622313 @default.
• W2757081551 cites W2066537714 @default.
• W2757081551 cites W2083864653 @default.
• W2757081551 cites W2102889066 @default.
• W2757081551 cites W2103388008 @default.
• W2757081551 cites W2104747419 @default.
• W2757081551 cites W2108255861 @default.
• W2757081551 cites W2108670003 @default.
• W2757081551 cites W2109783713 @default.
• W2757081551 cites W2112010689 @default.
• W2757081551 cites W2142634248 @default.
• W2757081551 cites W2149005864 @default.
• W2757081551 cites W2150641822 @default.
• W2757081551 cites W2151172480 @default.
• W2757081551 cites W2171191088 @default.
• W2757081551 cites W2280036172 @default.
• W2757081551 cites W2515382171 @default.
• W2757081551 cites W2621223038 @default.
• W2757081551 cites W4249037085 @default.
• W2757081551 doi "https://doi.org/10.1021/acs.bioconjchem.7b00324" @default.
• W2757081551 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28949511" @default.
• W2757081551 hasPublicationYear "2017" @default.
• W2757081551 type Work @default.
• W2757081551 sameAs 2757081551 @default.
• W2757081551 citedByCount "6" @default.
• W2757081551 countsByYear W27570815512018 @default.
• W2757081551 countsByYear W27570815512019 @default.
• W2757081551 countsByYear W27570815512022 @default.
• W2757081551 crossrefType "journal-article" @default.
• W2757081551 hasAuthorship W2757081551A5000519808 @default.
• W2757081551 hasAuthorship W2757081551A5029881551 @default.
• W2757081551 hasAuthorship W2757081551A5036401376 @default.
• W2757081551 hasAuthorship W2757081551A5060312536 @default.
• W2757081551 hasAuthorship W2757081551A5063750534 @default.
• W2757081551 hasAuthorship W2757081551A5067138179 @default.
• W2757081551 hasAuthorship W2757081551A5075423250 @default.
• W2757081551 hasConcept C108586683 @default.
• W2757081551 hasConcept C12554922 @default.
• W2757081551 hasConcept C128972844 @default.
• W2757081551 hasConcept C141071460 @default.
• W2757081551 hasConcept C150903083 @default.
• W2757081551 hasConcept C153911025 @default.
• W2757081551 hasConcept C179264091 @default.
• W2757081551 hasConcept C185592680 @default.
• W2757081551 hasConcept C188027245 @default.
• W2757081551 hasConcept C207001950 @default.
• W2757081551 hasConcept C2776694085 @default.
• W2757081551 hasConcept C2777421810 @default.
• W2757081551 hasConcept C2781303535 @default.
• W2757081551 hasConcept C55493867 @default.
• W2757081551 hasConcept C71924100 @default.
• W2757081551 hasConcept C79879829 @default.
• W2757081551 hasConcept C86803240 @default.
• W2757081551 hasConceptScore W2757081551C108586683 @default.
• W2757081551 hasConceptScore W2757081551C12554922 @default.
• W2757081551 hasConceptScore W2757081551C128972844 @default.
• W2757081551 hasConceptScore W2757081551C141071460 @default.
• W2757081551 hasConceptScore W2757081551C150903083 @default.
• W2757081551 hasConceptScore W2757081551C153911025 @default.
• W2757081551 hasConceptScore W2757081551C179264091 @default.
• W2757081551 hasConceptScore W2757081551C185592680 @default.
• W2757081551 hasConceptScore W2757081551C188027245 @default.
• W2757081551 hasConceptScore W2757081551C207001950 @default.
• W2757081551 hasConceptScore W2757081551C2776694085 @default.
• W2757081551 hasConceptScore W2757081551C2777421810 @default.
• W2757081551 hasConceptScore W2757081551C2781303535 @default.
• W2757081551 hasConceptScore W2757081551C55493867 @default.
• W2757081551 hasConceptScore W2757081551C71924100 @default.
• W2757081551 hasConceptScore W2757081551C79879829 @default.
• W2757081551 hasConceptScore W2757081551C86803240 @default.
• W2757081551 hasFunder F4320321001 @default.
• W2757081551 hasIssue "10" @default.

• next