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- W2757100609 abstract "TLR signaling is critical to innate immune system regulation; however, aberrant TLR signaling is involved in several diseases, including insulin resistance, Alzheimer's disease, and tumor metastasis. Moreover, a recent study found that TLR-4 signaling pathway inhibition might be a target for the suppression of chronic inflammatory disorders. In this article, we show that the green tea polyphenol epigallocatechin-3-O-gallate (EGCG) increases the expression of Toll interacting protein, a strong inhibitor of TLR4 signaling, by suppressing the expression of E74-like ETS transcription factor 1 (Elf-1). A mechanistic study revealed that EGCG suppressed Elf-1 expression via protein phosphatase 2A/cyclic GMP (cGMP)-dependent mechanisms. We also confirmed that orally administered EGCG and a cGMP inducer upregulated Toll interacting protein expression, increased intracellular levels of cGMP in macrophages, and suppressed Elf-1 expression. These data support EGCG and a cGMP inducer as potential candidate suppressors of TLR4 signaling." @default.
- W2757100609 created "2017-10-06" @default.
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- W2757100609 date "2017-09-27" @default.
- W2757100609 modified "2023-10-13" @default.
- W2757100609 title "Green Tea Polyphenol EGCG Upregulates Tollip Expression by Suppressing Elf-1 Expression" @default.
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- W2757100609 doi "https://doi.org/10.4049/jimmunol.1601822" @default.
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