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- W2757183771 endingPage "425" @default.
- W2757183771 startingPage "405" @default.
- W2757183771 abstract "A significant obstacle to the development of new brain tumor therapeutics remains the lack of rodent models that faithfully reproduce the in vivo complexities of human glioblastoma. Dogs and humans are the only species that frequently develop spontaneous brain tumors. Remarkable clinical, phenotypic, and molecular similarities exist between human and canine malignant glioma. Our research has focused on the development of pharmacologically tractable molecular targets common to human and canine gliomas, as well as the discovery and refinement of novel methods of drug delivery to the brain, such as convection-enhanced delivery (CED), irreversible electroporation (IRE), and focused ultrasound, that can overcome the limitations imposed by the blood–brain and blood–tumor barriers. Through the conduct of early phase clinical trials in dogs, we demonstrate the safety, feasibility, and preliminary efficacies of IL-13RA2- and EphA2-targeted bacterial cytotoxins and IRE for the treatment of spontaneous malignant glioma, illustrate the clinical utility of real-time imaging monitored CED as a robust drug delivery platform, and describe the use of the tumor-bearing dog in transcranial-focused ultrasound applications related to neuro-oncology. The dog brain cancer model offers unique opportunities to expedite the clinical translation of cancer therapeutics through the design of preclinical investigations that ask and answer drug and medical device development questions that cannot be sufficiently addressed in rodent models." @default.
- W2757183771 created "2017-10-06" @default.
- W2757183771 creator A5029454626 @default.
- W2757183771 date "2017-09-22" @default.
- W2757183771 modified "2023-09-30" @default.
- W2757183771 title "Maximizing Local Access to Therapeutic Deliveries in Glioblastoma. Part V: Clinically Relevant Model for Testing New Therapeutic Approaches" @default.
- W2757183771 cites W1543287659 @default.
- W2757183771 cites W1553534857 @default.
- W2757183771 cites W1561080590 @default.
- W2757183771 cites W1660607775 @default.
- W2757183771 cites W1669689152 @default.
- W2757183771 cites W1762678393 @default.
- W2757183771 cites W1828918919 @default.
- W2757183771 cites W1899723132 @default.
- W2757183771 cites W1905089437 @default.
- W2757183771 cites W1947261965 @default.
- W2757183771 cites W1968036885 @default.
- W2757183771 cites W1971681203 @default.
- W2757183771 cites W1977666575 @default.
- W2757183771 cites W1980958559 @default.
- W2757183771 cites W1983274306 @default.
- W2757183771 cites W1995969484 @default.
- W2757183771 cites W1996935297 @default.
- W2757183771 cites W1999676774 @default.
- W2757183771 cites W1999680472 @default.
- W2757183771 cites W2001711537 @default.
- W2757183771 cites W2004155851 @default.
- W2757183771 cites W2005371778 @default.
- W2757183771 cites W2010098122 @default.
- W2757183771 cites W2010793111 @default.
- W2757183771 cites W2010869577 @default.
- W2757183771 cites W2011367738 @default.
- W2757183771 cites W2011509488 @default.
- W2757183771 cites W2011526661 @default.
- W2757183771 cites W2011704245 @default.
- W2757183771 cites W2017741298 @default.
- W2757183771 cites W2019068717 @default.
- W2757183771 cites W2025183726 @default.
- W2757183771 cites W2026431467 @default.
- W2757183771 cites W2028342551 @default.
- W2757183771 cites W2033921873 @default.
- W2757183771 cites W2037342314 @default.
- W2757183771 cites W2040789205 @default.
- W2757183771 cites W2045624488 @default.
- W2757183771 cites W2046449631 @default.
- W2757183771 cites W2046641698 @default.
- W2757183771 cites W2049958682 @default.
- W2757183771 cites W2055872151 @default.
- W2757183771 cites W2057207364 @default.
- W2757183771 cites W2065685950 @default.
- W2757183771 cites W2068011093 @default.
- W2757183771 cites W2070639102 @default.
- W2757183771 cites W2076392028 @default.
- W2757183771 cites W2084873067 @default.
- W2757183771 cites W2085595681 @default.
- W2757183771 cites W2087331882 @default.
- W2757183771 cites W2087739327 @default.
- W2757183771 cites W2088499309 @default.
- W2757183771 cites W2089531514 @default.
- W2757183771 cites W2094621092 @default.
- W2757183771 cites W2095154356 @default.
- W2757183771 cites W2096287682 @default.
- W2757183771 cites W2097658609 @default.
- W2757183771 cites W2098395274 @default.
- W2757183771 cites W2098816456 @default.
- W2757183771 cites W2099532095 @default.
- W2757183771 cites W2101190482 @default.
- W2757183771 cites W2102855395 @default.
- W2757183771 cites W2104165523 @default.
- W2757183771 cites W2108627173 @default.
- W2757183771 cites W2110979595 @default.
- W2757183771 cites W2119456602 @default.
- W2757183771 cites W2127787180 @default.
- W2757183771 cites W2131702292 @default.
- W2757183771 cites W2134807618 @default.
- W2757183771 cites W2135062838 @default.
- W2757183771 cites W2135428178 @default.
- W2757183771 cites W2143044248 @default.
- W2757183771 cites W2145000920 @default.
- W2757183771 cites W2148276738 @default.
- W2757183771 cites W2151264866 @default.
- W2757183771 cites W2152042738 @default.
- W2757183771 cites W2154915010 @default.
- W2757183771 cites W2160382843 @default.
- W2757183771 cites W2161289668 @default.
- W2757183771 cites W2164076826 @default.
- W2757183771 cites W2164088832 @default.
- W2757183771 cites W2165510365 @default.
- W2757183771 cites W2172501680 @default.
- W2757183771 cites W2274959647 @default.
- W2757183771 cites W2388784306 @default.
- W2757183771 cites W2393820387 @default.
- W2757183771 cites W2403860924 @default.
- W2757183771 cites W4229594069 @default.
- W2757183771 cites W4242403727 @default.
- W2757183771 cites W4245392732 @default.
- W2757183771 cites W4254021855 @default.
- W2757183771 doi "https://doi.org/10.15586/codon.glioblastoma.2017.ch21" @default.