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• W2757193208 abstract "Mathematical models for TGF-β and IL-6 signalling have been linked, providing a platform for analyzing the crosstalk between the systems. An integrated IL-6:TGF-β model was developed via a reduced set of reaction equations which incorporate both feedback loops and appropriate time-delays for transcription and translation processes. The model simulates stable, robust and realistic responses to both ligands. Pulsatile (multiple pulses) inputs for both TGF-β and IL-6 have been simulated to investigate the effects of each ligand on the sensitivity, equilibrium and dynamic responses of the integrated signalling system. In our simulations the crosstalk between constant IL-6 and TGF-β signalling via SMAD7 does not appear to be sufficient to render the cells resistant to TGF-β inhibition. However, the simulations predict that pulsatile IL-6 stimulation would increase SMAD7 levels substantially and consequentially, lead to resistance to TGF-β. The model also allows the prediction of the integrated signalling pathway responses to the mutation of key components, e.g. Gp130 F/F." @default.
• W2757193208 created "2017-10-06" @default.
• W2757193208 creator A5006422609 @default.
• W2757193208 creator A5045068271 @default.
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• W2757193208 creator A5086602150 @default.
• W2757193208 creator A5088957393 @default.
• W2757193208 date "2017-05-04" @default.
• W2757193208 modified "2023-10-03" @default.
• W2757193208 title "TGF-β and IL-6 family signalling crosstalk: an integrated model" @default.
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