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• W2757200818 abstract "Amblyopia is a relatively common (incidence 3%) developmental disorder in which there is loss of vision as a consequence of a disruption to normal visual development. Although the deficit is monocular and known to be of cortical origin, the nature of the processing deficit is controversial. Human behavioral studies have identified two main deficits — a loss of contrast sensitivity and perceived spatial distortions. Here we use a multifocal fMRI approach to ascertain, in a group of anisometropic amblyopes, whether these two deficits have a single common cause or whether they are the result of two underlying independent cortical disorders. We found that fMRI magnitudes were attenuated in amblyopic eye stimulation, and that there was poor fidelity for co-localization of the activity clusters between the amblyopic and fellow-fixing eye stimulation. These effects varied across eccentricities and correlate with the degree of amblyopia but not with one another, suggesting two independent cortical deficits: a reduced responsiveness as well as reduced fidelity of spatial representation. These deficits are independent of eccentricity within the central field and consistent across early cortical visual areas." @default.
• W2757200818 created "2017-10-06" @default.
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• W2757200818 date "2019-04-01" @default.
• W2757200818 modified "2023-10-14" @default.
• W2757200818 title "Two cortical deficits underlie amblyopia: A multifocal fMRI analysis" @default.
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• W2757200818 doi "https://doi.org/10.1016/j.neuroimage.2017.09.045" @default.
• W2757200818 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28943411" @default.
• W2757200818 hasPublicationYear "2019" @default.
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