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- W2757237547 endingPage "417" @default.
- W2757237547 startingPage "347" @default.
- W2757237547 abstract "Alzheimer’s disease is one of the leading causes of deaths in both developed as well as developing countries. It is characterized mainly by the deposition of extracellular β-amyloid plaques and intracellular neurofibrillary tangles. To date various hypotheses regarding the aetiology of AD have been reported in the literature, but the exact cause of AD still remains unknown. Hyperphosphorylation of tau protein is considered as one of the most accepted reasons by the scientists and researchers throughout the world. Currently, four FDA-approved drugs (rivastigmine, galantamine, donepezil, memantine) are available in the market, and the fifth one (tacrine) is withdrawn due its hepatotoxicity concerns. Protein kinases are well-known targets in cancer, and several reports are available regarding their critical role in the hyperphosphorylation of tau protein in AD. Although not even a single molecule is available in the market for the treatment of AD as a kinase inhibitor, a number of studies are in the pipeline targeting the kinases. In this chapter efforts have been made to discuss the computational studies carried out till date on various protein kinases in search of potential anti-Alzheimer’s agents." @default.
- W2757237547 created "2017-10-06" @default.
- W2757237547 creator A5011973371 @default.
- W2757237547 creator A5030484615 @default.
- W2757237547 creator A5057409261 @default.
- W2757237547 creator A5081037246 @default.
- W2757237547 date "2017-09-28" @default.
- W2757237547 modified "2023-10-07" @default.
- W2757237547 title "Computational Modelling of Kinase Inhibitors as Anti-Alzheimer Agents" @default.
- W2757237547 cites W1264856134 @default.
- W2757237547 cites W1484266107 @default.
- W2757237547 cites W1491121534 @default.
- W2757237547 cites W1529185793 @default.
- W2757237547 cites W1540112213 @default.
- W2757237547 cites W1545201063 @default.
- W2757237547 cites W1549626617 @default.
- W2757237547 cites W1557240175 @default.
- W2757237547 cites W1598852457 @default.
- W2757237547 cites W1930179398 @default.
- W2757237547 cites W1957658076 @default.
- W2757237547 cites W1964074342 @default.
- W2757237547 cites W1964378600 @default.
- W2757237547 cites W1964892539 @default.
- W2757237547 cites W1965909642 @default.
- W2757237547 cites W1970197612 @default.
- W2757237547 cites W1971140803 @default.
- W2757237547 cites W1974015070 @default.
- W2757237547 cites W1974075485 @default.
- W2757237547 cites W1975101337 @default.
- W2757237547 cites W1977605283 @default.
- W2757237547 cites W1977969546 @default.
- W2757237547 cites W1984984016 @default.
- W2757237547 cites W1985139403 @default.
- W2757237547 cites W1989404928 @default.
- W2757237547 cites W1990565657 @default.
- W2757237547 cites W1990752558 @default.
- W2757237547 cites W1993338136 @default.
- W2757237547 cites W1994447976 @default.
- W2757237547 cites W1995576455 @default.
- W2757237547 cites W1997485731 @default.
- W2757237547 cites W1998440070 @default.
- W2757237547 cites W2000088111 @default.
- W2757237547 cites W2004743013 @default.
- W2757237547 cites W2005766257 @default.
- W2757237547 cites W2011253324 @default.
- W2757237547 cites W2014387540 @default.
- W2757237547 cites W2014686354 @default.
- W2757237547 cites W2016712107 @default.
- W2757237547 cites W2018423808 @default.
- W2757237547 cites W2018607550 @default.
- W2757237547 cites W2019352357 @default.
- W2757237547 cites W2019619408 @default.
- W2757237547 cites W2020793386 @default.
- W2757237547 cites W2022513026 @default.
- W2757237547 cites W2022748595 @default.
- W2757237547 cites W2025426093 @default.
- W2757237547 cites W2028867134 @default.
- W2757237547 cites W2030205108 @default.
- W2757237547 cites W2031443046 @default.
- W2757237547 cites W2032857162 @default.
- W2757237547 cites W2035585923 @default.
- W2757237547 cites W2036384121 @default.
- W2757237547 cites W2040410288 @default.
- W2757237547 cites W2041848124 @default.
- W2757237547 cites W2046033738 @default.
- W2757237547 cites W2052366943 @default.
- W2757237547 cites W2053106209 @default.
- W2757237547 cites W2053396751 @default.
- W2757237547 cites W2055075860 @default.
- W2757237547 cites W2057808145 @default.
- W2757237547 cites W2060813110 @default.
- W2757237547 cites W2062224156 @default.
- W2757237547 cites W2063044400 @default.
- W2757237547 cites W2063193324 @default.
- W2757237547 cites W2063421477 @default.
- W2757237547 cites W2063511018 @default.
- W2757237547 cites W2066418831 @default.
- W2757237547 cites W2066694751 @default.
- W2757237547 cites W2068336600 @default.
- W2757237547 cites W2068535486 @default.
- W2757237547 cites W2069330740 @default.
- W2757237547 cites W2070186790 @default.
- W2757237547 cites W2071508092 @default.
- W2757237547 cites W2072880750 @default.
- W2757237547 cites W2074981365 @default.
- W2757237547 cites W2075237564 @default.
- W2757237547 cites W2077733632 @default.
- W2757237547 cites W2081858180 @default.
- W2757237547 cites W2084043574 @default.
- W2757237547 cites W2086286404 @default.
- W2757237547 cites W2089353165 @default.
- W2757237547 cites W2091455173 @default.
- W2757237547 cites W2092785809 @default.
- W2757237547 cites W2097073373 @default.
- W2757237547 cites W2098759196 @default.
- W2757237547 cites W2105047045 @default.
- W2757237547 cites W2109558456 @default.
- W2757237547 cites W2110089433 @default.