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• W2757243721 abstract "Di (ethylhexyl) phthalate (DEHP) is a commonly used phthalates (PAEs) compound as plasticizer and becomes a severe environmental pollutant worldwide. Studies show that DEHP, as an environmental endocrine disruptor, has potential adverse effects on human. Epidemiologic studies indicate that DEHP is positively correlated to allergic diseases. Maternal exposure to DEHP may contribute to the increasing incidence of allergic diseases in offspring. However, the role of DEHP and its detailed mechanism in allergic disease of the offspring are still unclear. The aim of our study is to investigate whether DEHP maternal exposure could aggravate the allergic responses in offspring and its mechanism. Pregnant Wistar rats were randomly divided into three groups and exposed to different doses of DEHP. Half of the offspring were challenged with OVA after birth. All the pups of each group were sacrificed at postnatal day (PND)14, PND21 and PND28. The number of inflammatory cells in bronchoalveolar lavage was counted, lung pathological changes were observed, Th2 type cytokines expressions were checked, and the expression of TSLP signaling pathway were examined. Our results showed that maternal exposure to DEHP during pregnancy and lactation aggravated the eosinophils accumulation and the pathological inflammatory changes in pups' lung after OVA challenge. And maternal exposure to DEHP during pregnancy and lactation also elevated the levels of typical Th2 cytokines in OVA-challenged rats. What's more, maternal exposure to DEHP during pregnancy and lactation increased the levels of TSLP, TSLPR and IL-7R in the offspring after OVA challenge. Our study suggested that DEHP maternal exposure could aggravate the OVA-induced asthmatic responses in offspring. And this adjuvant effect of DEHP was related with the TSLP/TSLPR/IL-7R and its downstream signal pathways." @default.
• W2757243721 created "2017-10-06" @default.
• W2757243721 creator A5003753200 @default.
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• W2757243721 date "2018-02-01" @default.
• W2757243721 modified "2023-09-25" @default.
• W2757243721 title "Maternal exposure to environmental DEHP exacerbated OVA-induced asthmatic responses in rat offspring" @default.
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• W2757243721 cites W1983959232 @default.
• W2757243721 cites W1993525891 @default.
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• W2757243721 doi "https://doi.org/10.1016/j.scitotenv.2017.09.276" @default.
• W2757243721 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28972901" @default.
• W2757243721 hasPublicationYear "2018" @default.
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