FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2757244512> ?p ?o ?g. }

• W2757244512 abstract "Mast cell activation via the high-affinity IgE receptor (FceRI) elicits production of inflammatory mediators central to allergic disease. As a synthetic antioxidant and a potent ribonucleotide reductase (RNR) inhibitor, Didox (3,4-dihyroxybenzohydroxamic acid) has been tested in clinical trials for cancer and is an attractive therapeutic for inflammatory disease. We found that Didox treatment of mouse bone marrow-derived mast cells (BMMC) reduced IgE-stimulated degranulation and cytokine production, including IL-6, IL-13, TNF and MIP-1a (CCL3). These effects were consistent using BMMC of different genetic backgrounds and peritoneal mast cells. While the RNR inhibitor hydroxyurea had little or no effect on IgE-mediated function, high concentrations of the antioxidant N-acetylcysteine mimicked Didox-mediated suppression. Furthermore, Didox increased expression of the antioxidant genes superoxide dismutase and catalase, and suppressed DCFH-DA fluorescence, indicating reduced reactive oxygen species production. Didox effects were not due to changes in FceRI expression or cell viability, suggesting it inhibits signaling required for inflammatory cytokine production. In support of this, we found that Didox reduced FceRI-mediated AP-1 and NFκB transcriptional activity. Finally, Didox suppressed mast cell-dependent, IgE-mediated passive systemic anaphylaxis in vivo. These data demonstrate the potential use for Didox asa means of antagonizing mast cell responses in allergic disease." @default.
• W2757244512 created "2017-10-06" @default.
• W2757244512 creator A5011166377 @default.
• W2757244512 creator A5018572678 @default.
• W2757244512 creator A5055009761 @default.
• W2757244512 creator A5055353858 @default.
• W2757244512 creator A5072349594 @default.
• W2757244512 creator A5074459288 @default.
• W2757244512 creator A5082176880 @default.
• W2757244512 creator A5084139344 @default.
• W2757244512 creator A5089099811 @default.
• W2757244512 creator A5090348719 @default.
• W2757244512 creator A5091172811 @default.
• W2757244512 date "2017-12-01" @default.
• W2757244512 modified "2023-10-15" @default.
• W2757244512 title "Didox (3,4-dihydroxybenzohydroxamic acid) suppresses IgE-mediated mast cell activation through attenuation of NFκB and AP-1 transcription" @default.
• W2757244512 cites W1503586314 @default.
• W2757244512 cites W1512072225 @default.
• W2757244512 cites W1526883212 @default.
• W2757244512 cites W1538463079 @default.
• W2757244512 cites W1542443684 @default.
• W2757244512 cites W1596026758 @default.
• W2757244512 cites W1650401181 @default.
• W2757244512 cites W1900973879 @default.
• W2757244512 cites W1942586809 @default.
• W2757244512 cites W1968366630 @default.
• W2757244512 cites W1968835396 @default.
• W2757244512 cites W1970653879 @default.
• W2757244512 cites W1972447401 @default.
• W2757244512 cites W1972910214 @default.
• W2757244512 cites W1981034102 @default.
• W2757244512 cites W1981703791 @default.
• W2757244512 cites W1982709334 @default.
• W2757244512 cites W1984503538 @default.
• W2757244512 cites W1991584531 @default.
• W2757244512 cites W1991788308 @default.
• W2757244512 cites W1992071502 @default.
• W2757244512 cites W1997684038 @default.
• W2757244512 cites W2000710891 @default.
• W2757244512 cites W2004148398 @default.
• W2757244512 cites W2015485550 @default.
• W2757244512 cites W2016269970 @default.
• W2757244512 cites W2023498522 @default.
• W2757244512 cites W2024828070 @default.
• W2757244512 cites W2025090029 @default.
• W2757244512 cites W2032979234 @default.
• W2757244512 cites W2038355016 @default.
• W2757244512 cites W2046445746 @default.
• W2757244512 cites W2049190372 @default.
• W2757244512 cites W2050525007 @default.
• W2757244512 cites W2051930121 @default.
• W2757244512 cites W2055319158 @default.
• W2757244512 cites W2061701719 @default.
• W2757244512 cites W2067430655 @default.
• W2757244512 cites W2069184506 @default.
• W2757244512 cites W2079866862 @default.
• W2757244512 cites W2092891785 @default.
• W2757244512 cites W2095526757 @default.
• W2757244512 cites W2098185034 @default.
• W2757244512 cites W2114043889 @default.
• W2757244512 cites W2116094707 @default.
• W2757244512 cites W2116339975 @default.
• W2757244512 cites W2119621206 @default.
• W2757244512 cites W2132224342 @default.
• W2757244512 cites W2136463978 @default.
• W2757244512 cites W2145414107 @default.
• W2757244512 cites W2172263281 @default.
• W2757244512 cites W2182991829 @default.
• W2757244512 cites W2206776658 @default.
• W2757244512 cites W2260572233 @default.
• W2757244512 cites W2408822504 @default.
• W2757244512 cites W2414781137 @default.
• W2757244512 cites W2500321297 @default.
• W2757244512 cites W2514386944 @default.
• W2757244512 cites W2560874492 @default.
• W2757244512 cites W2735586972 @default.
• W2757244512 cites W33343212 @default.
• W2757244512 cites W336280843 @default.
• W2757244512 doi "https://doi.org/10.1016/j.cellimm.2017.09.008" @default.
• W2757244512 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5733711" @default.
• W2757244512 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28964543" @default.
• W2757244512 hasPublicationYear "2017" @default.
• W2757244512 type Work @default.
• W2757244512 sameAs 2757244512 @default.
• W2757244512 citedByCount "2" @default.
• W2757244512 countsByYear W27572445122018 @default.
• W2757244512 countsByYear W27572445122019 @default.
• W2757244512 crossrefType "journal-article" @default.
• W2757244512 hasAuthorship W2757244512A5011166377 @default.
• W2757244512 hasAuthorship W2757244512A5018572678 @default.
• W2757244512 hasAuthorship W2757244512A5055009761 @default.
• W2757244512 hasAuthorship W2757244512A5055353858 @default.
• W2757244512 hasAuthorship W2757244512A5072349594 @default.
• W2757244512 hasAuthorship W2757244512A5074459288 @default.
• W2757244512 hasAuthorship W2757244512A5082176880 @default.
• W2757244512 hasAuthorship W2757244512A5084139344 @default.
• W2757244512 hasAuthorship W2757244512A5089099811 @default.
• W2757244512 hasAuthorship W2757244512A5090348719 @default.
• W2757244512 hasAuthorship W2757244512A5091172811 @default.
• W2757244512 hasBestOaLocation W27572445122 @default.

• next