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- W2757247712 endingPage "3570" @default.
- W2757247712 startingPage "3551" @default.
- W2757247712 abstract "The kinetochore is a large, evolutionarily conserved protein structure that connects chromosomes with microtubules. During chromosome segregation, outer kinetochore components track depolymerizing ends of microtubules to facilitate the separation of chromosomes into two cells. In budding yeast, each chromosome has a point centromere upon which a single kinetochore is built, which attaches to a single microtubule. This defined architecture facilitates quantitative examination of kinetochores during the cell cycle. Using three independent measures—calibrated imaging, FRAP, and photoconversion—we find that the Dam1 submodule is unchanged during anaphase, whereas MIND and Ndc80 submodules add copies to form an “anaphase configuration” kinetochore. Microtubule depolymerization and kinesin-related motors contribute to copy addition. Mathematical simulations indicate that the addition of microtubule attachments could facilitate tracking during rapid microtubule depolymerization. We speculate that the minimal kinetochore configuration, which exists from G1 through metaphase, allows for correction of misattachments. Our study provides insight into dynamics and plasticity of the kinetochore structure during chromosome segregation in living cells." @default.
- W2757247712 created "2017-10-06" @default.
- W2757247712 creator A5016119539 @default.
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- W2757247712 creator A5046618864 @default.
- W2757247712 creator A5046711304 @default.
- W2757247712 creator A5067830488 @default.
- W2757247712 creator A5074105995 @default.
- W2757247712 date "2017-09-22" @default.
- W2757247712 modified "2023-10-11" @default.
- W2757247712 title "Structural plasticity of the living kinetochore" @default.
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- W2757247712 doi "https://doi.org/10.1083/jcb.201703152" @default.
- W2757247712 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5674893" @default.