Matches in SemOpenAlex for { <https://semopenalex.org/work/W2757291679> ?p ?o ?g. }
- W2757291679 endingPage "2098" @default.
- W2757291679 startingPage "2089" @default.
- W2757291679 abstract "Objective: To provide a narrative review of the latest concepts and understanding of the pathophysiology of critical illness-related corticosteroid insufficiency (CIRCI). Participants: A multi-specialty task force of international experts in critical care medicine and endocrinology and members of the Society of Critical Care Medicine and the European Society of Intensive Care Medicine. Data Sources: Medline, Database of Abstracts of Reviews of Effects (DARE), Cochrane Central Register of Controlled Trials (CENTRAL) and the Cochrane Database of Systematic Reviews. Results: Three major pathophysiologic events were considered to constitute CIRCI: dysregulation of the hypothalamic–pituitary–adrenal (HPA) axis, altered cortisol metabolism, and tissue resistance to glucocorticoids. The dysregulation of the HPA axis is complex, involving multidirectional crosstalk between the CRH/ACTH pathways, autonomic nervous system, vasopressinergic system, and immune system. Recent studies have demonstrated that plasma clearance of cortisol is markedly reduced during critical illness, explained by suppressed expression and activity of the primary cortisol-metabolizing enzymes in the liver and kidney. Despite the elevated cortisol levels during critical illness, tissue resistance to glucocorticoids is believed to occur due to insufficient glucocorticoid alpha-mediated anti-inflammatory activity. Conclusions: Novel insights into the pathophysiology of CIRCI add to the limitations of the current diagnostic tools to identify at-risk patients and may also impact how corticosteroids are used in patients with CIRCI." @default.
- W2757291679 created "2017-10-06" @default.
- W2757291679 creator A5010324154 @default.
- W2757291679 creator A5012028041 @default.
- W2757291679 creator A5019278117 @default.
- W2757291679 creator A5026092082 @default.
- W2757291679 creator A5039317852 @default.
- W2757291679 creator A5042145557 @default.
- W2757291679 creator A5046677888 @default.
- W2757291679 creator A5048385516 @default.
- W2757291679 creator A5057719739 @default.
- W2757291679 creator A5062367983 @default.
- W2757291679 creator A5068616089 @default.
- W2757291679 creator A5073463366 @default.
- W2757291679 creator A5075635162 @default.
- W2757291679 creator A5077828570 @default.
- W2757291679 creator A5084671289 @default.
- W2757291679 creator A5090576091 @default.
- W2757291679 date "2017-12-01" @default.
- W2757291679 modified "2023-10-15" @default.
- W2757291679 title "Critical Illness-Related Corticosteroid Insufficiency (CIRCI): A Narrative Review from a Multispecialty Task Force of the Society of Critical Care Medicine (SCCM) and the European Society of Intensive Care Medicine (ESICM)" @default.
- W2757291679 cites W1818595191 @default.
- W2757291679 cites W1926858954 @default.
- W2757291679 cites W1954843732 @default.
- W2757291679 cites W1956725602 @default.
- W2757291679 cites W1966453802 @default.
- W2757291679 cites W1970943114 @default.
- W2757291679 cites W1978262109 @default.
- W2757291679 cites W1981078229 @default.
- W2757291679 cites W1981722357 @default.
- W2757291679 cites W1987467309 @default.
- W2757291679 cites W1991258858 @default.
- W2757291679 cites W1992339013 @default.
- W2757291679 cites W1995754480 @default.
- W2757291679 cites W1996484645 @default.
- W2757291679 cites W1998718117 @default.
- W2757291679 cites W2003242778 @default.
- W2757291679 cites W2007130516 @default.
- W2757291679 cites W2012983034 @default.
- W2757291679 cites W2015465856 @default.
- W2757291679 cites W2015843044 @default.
- W2757291679 cites W2019728240 @default.
- W2757291679 cites W2020222089 @default.
- W2757291679 cites W2021396499 @default.
- W2757291679 cites W2025294283 @default.
- W2757291679 cites W2030868040 @default.
- W2757291679 cites W2031670669 @default.
- W2757291679 cites W2033465735 @default.
- W2757291679 cites W2034443456 @default.
- W2757291679 cites W2034896517 @default.
- W2757291679 cites W2035072797 @default.
- W2757291679 cites W2036370867 @default.
- W2757291679 cites W2047162021 @default.
- W2757291679 cites W2051145954 @default.
- W2757291679 cites W2057351433 @default.
- W2757291679 cites W2062297873 @default.
- W2757291679 cites W2063399544 @default.
- W2757291679 cites W2063579231 @default.
- W2757291679 cites W2069200792 @default.
- W2757291679 cites W2074256942 @default.
- W2757291679 cites W2075114528 @default.
- W2757291679 cites W2076127324 @default.
- W2757291679 cites W2083104211 @default.
- W2757291679 cites W2084464257 @default.
- W2757291679 cites W2084883365 @default.
- W2757291679 cites W2087605866 @default.
- W2757291679 cites W2096846771 @default.
- W2757291679 cites W2097364950 @default.
- W2757291679 cites W2100018795 @default.
- W2757291679 cites W2104968736 @default.
- W2757291679 cites W2105981152 @default.
- W2757291679 cites W2107946840 @default.
- W2757291679 cites W2114889885 @default.
- W2757291679 cites W2120094753 @default.
- W2757291679 cites W2120348732 @default.
- W2757291679 cites W2121855288 @default.
- W2757291679 cites W2124034004 @default.
- W2757291679 cites W2133744202 @default.
- W2757291679 cites W2135682252 @default.
- W2757291679 cites W2141778986 @default.
- W2757291679 cites W2142503879 @default.
- W2757291679 cites W2142927411 @default.
- W2757291679 cites W2143734001 @default.
- W2757291679 cites W2146562666 @default.
- W2757291679 cites W2146693123 @default.
- W2757291679 cites W2148049376 @default.
- W2757291679 cites W2148507530 @default.
- W2757291679 cites W2153354364 @default.
- W2757291679 cites W2158930864 @default.
- W2757291679 cites W2159197384 @default.
- W2757291679 cites W2166078776 @default.
- W2757291679 cites W2167220607 @default.
- W2757291679 cites W2277519291 @default.
- W2757291679 cites W2293709786 @default.
- W2757291679 cites W2412545608 @default.
- W2757291679 cites W2484033988 @default.
- W2757291679 cites W2520261351 @default.
- W2757291679 cites W2587941297 @default.