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- W2757303679 abstract "Background : Tacrolimus is an immunosuppressant drug which used after organ transplantation to prevent rejection of transplanted organs. Tacrolimus causes nephrotoxicity, hepatotoxicity, and diabetogenicity. Aged black garlic (ABG) is garlic-processed product and it was found to show more antioxidant activity than fresh garlic. Materials and methods: Four groups of rats were used. Group1: control, Group 2: orally given aged black garlic, Group 3: administrated orally by Tacrolimus, Group 4: treated with ABG and Tac. Histological, morphometric, immunohistochemical and biochemical alterations, were investigated in testicular tissue and serum. Results : Tacrolimus induced histological alteration in testicular tissue as , blood vessels congestions, vaculation , and degeneration. Moreover, diameter and epithelial height of seminiferous tubules was decreased significantly. Tacrolimus decreased expression of PCNA and increased BCL-2 expression. Testosterone, progesterone and LH levels were reduced in serum. Tacrolimus decreased the oxidative statues in testicular tissue. Treating rats with ABG and tacrolimus ameliorated all histopathological and toxicological changes induced by Tac, testicular tissue architecture returned to normal status, a significant increase in tubular diameter and in germinal epithelia was recorded. Moreover, an increase in the expression of PCNA and decrease in the expression of Bcl-2 were observed. ABG increased testosterone, progesterone and LH hormones levels in serum , and antioxidant enzymes in testicular tissues. On the other hand, MDA levels were significantly decreased. Conclusion: Tacrolimus caused pathological alterations in testes of rats while ABG ameliorated these alterations." @default.
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- W2757303679 date "2017-09-23" @default.
- W2757303679 modified "2023-09-24" @default.
- W2757303679 title "Effect of Aged Black Garlic on Reproductive Toxicity induced by Tacrolimus in Male Rats : Histological and Immunohistochemical studies" @default.
- W2757303679 hasPublicationYear "2017" @default.
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