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• W2757335035 abstract "Abstract Both the subthalamic nucleus ( STN ) and the globus pallidus pars interna ( GP i) are major targets for neuromodulation therapy for movement disorders. An example of such a therapy is deep brain stimulation ( DBS ). The striatum is the primary target for pharmacological treatment of these disorders. To further our understanding of both the functional relationships among motor nuclei and the mechanisms of therapies for movement disorders, it is important to clarify how changing the neuronal activity of one target, either by medication or by artificial electrical stimulation, affects the other connected nuclei. To investigate this point, we recorded single‐unit activity from tonically active neurons ( TAN s), which are putative cholinergic interneurons in the striatum, of healthy monkeys ( Macaca fuscata ) during electrical stimulation of the STN or GP i. Both STN stimulation and GP i stimulation reduced the TAN spike rate. Local infusion of a D2 receptor antagonist in the striatum blocked the reduction in spike rate induced by STN stimulation but not that induced by GP i stimulation. Further, STN stimulation induced phasic dopamine release in the striatum as revealed by in vivo fast‐scan cyclic voltammetry. These results suggest the presence of multiple, strong functional relationships among the STN , GP i, and striatum that have different pathways and imply distinct therapeutic mechanisms for STN ‐ and GP i‐ DBS ." @default.
• W2757335035 created "2017-10-06" @default.
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• W2757335035 date "2017-10-20" @default.
• W2757335035 modified "2023-10-16" @default.
• W2757335035 title "Subthalamic nucleus and globus pallidus interna influence firing of tonically active neurons in the primate striatum through different mechanisms" @default.
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• W2757335035 doi "https://doi.org/10.1111/ejn.13726" @default.
• W2757335035 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5765455" @default.
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• W2757335035 hasPublicationYear "2017" @default.
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