FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2757383585> ?p ?o ?g. }

• W2757383585 abstract "Abstract Objectives The aim of this study was to evaluate the antiepileptic effects of opipramol, a sigma receptor agonist, diazepam, ketamine, an N-methyl-d-Aspartate (NMDA) receptor antagonist, and dantrolene, a ryanodine receptor antagonist, against caffeine-induced seizures in mice. Methods We used caffeine (1000 mg/kg) intraperitoneally for inducing clonic and tonic-clonic seizures in male albino Swiss strain of mice. We used opipramol in three different doses (10, 20 and 50 mg/kg), ketamine (50 mg/kg), dantrolene (40 mg/kg), opipramol (20 mg/kg) plus ketamine (50 mg/kg), opipramol (20 mg/kg) plus dantrolene (40 mg/kg), diazepam (5 mg/kg as a positive control) and the vehicle 30 min before injecting caffeine. We recorded the onset of clonic, tonic-clonic seizures and the time of death of animals after using caffeine. Results Animals treated with opipramol at a dose of 50 mg/kg or diazepam had a higher onset of clonic seizure compared with the vehicle-treated group. Dantrolene alone or with opipramol (20 mg/kg) increased the latency of clonic seizure compared with the control group. Opipramol (20 and 50 mg/kg), diazepam, ketamine alone or with opipramol, and dantrolene plus opipramol increased the latency of tonic-clonic seizures in mice. All the treatments except opipramol (10 mg/kg) and dantrolene alone increased the latency of death of animals. Conclusion Opipramol attenuated seizures produced by high doses of caffeine. Moreover, the activation of sigma receptors and inhibition of ryanodine receptors may produce synergistic effects against caffeine-induced seizures. Our study may imply that different mechanisms such as inhibition of gamma-aminobutyric acid-A receptors, activation of NMDA and ryanodine receptors may contribute to the caffeine-induced seizures." @default.
• W2757383585 created "2017-10-06" @default.
• W2757383585 creator A5037977591 @default.
• W2757383585 creator A5067797098 @default.
• W2757383585 creator A5070623010 @default.
• W2757383585 date "2017-12-01" @default.
• W2757383585 modified "2023-09-24" @default.
• W2757383585 title "Amelioration of caffeine-induced seizures by modulators of sigma, N-methyl-d-Aspartate and ryanodine receptors in mice" @default.
• W2757383585 cites W1482130984 @default.
• W2757383585 cites W1533559637 @default.
• W2757383585 cites W1966405252 @default.
• W2757383585 cites W1971774871 @default.
• W2757383585 cites W1978408389 @default.
• W2757383585 cites W1981694706 @default.
• W2757383585 cites W1983523517 @default.
• W2757383585 cites W1984604900 @default.
• W2757383585 cites W1991398727 @default.
• W2757383585 cites W2007758642 @default.
• W2757383585 cites W2012553932 @default.
• W2757383585 cites W2019625176 @default.
• W2757383585 cites W2038468284 @default.
• W2757383585 cites W2043883247 @default.
• W2757383585 cites W2051880791 @default.
• W2757383585 cites W2055681053 @default.
• W2757383585 cites W2055907731 @default.
• W2757383585 cites W2057707791 @default.
• W2757383585 cites W2060382131 @default.
• W2757383585 cites W2065965042 @default.
• W2757383585 cites W2066191400 @default.
• W2757383585 cites W2066857662 @default.
• W2757383585 cites W2071230782 @default.
• W2757383585 cites W2079274909 @default.
• W2757383585 cites W2087609871 @default.
• W2757383585 cites W2091422939 @default.
• W2757383585 cites W2095033319 @default.
• W2757383585 cites W2104797751 @default.
• W2757383585 cites W2114403556 @default.
• W2757383585 cites W2122054000 @default.
• W2757383585 cites W2171245354 @default.
• W2757383585 cites W2172295889 @default.
• W2757383585 cites W2335147441 @default.
• W2757383585 doi "https://doi.org/10.1016/j.ijep.2017.09.003" @default.
• W2757383585 hasPublicationYear "2017" @default.
• W2757383585 type Work @default.
• W2757383585 sameAs 2757383585 @default.
• W2757383585 citedByCount "0" @default.
• W2757383585 crossrefType "journal-article" @default.
• W2757383585 hasAuthorship W2757383585A5037977591 @default.
• W2757383585 hasAuthorship W2757383585A5067797098 @default.
• W2757383585 hasAuthorship W2757383585A5070623010 @default.
• W2757383585 hasBestOaLocation W27573835851 @default.
• W2757383585 hasConcept C126322002 @default.
• W2757383585 hasConcept C131783052 @default.
• W2757383585 hasConcept C134018914 @default.
• W2757383585 hasConcept C170493617 @default.
• W2757383585 hasConcept C185592680 @default.
• W2757383585 hasConcept C2776175493 @default.
• W2757383585 hasConcept C2776885963 @default.
• W2757383585 hasConcept C2778409475 @default.
• W2757383585 hasConcept C2778500429 @default.
• W2757383585 hasConcept C2780795376 @default.
• W2757383585 hasConcept C2781460320 @default.
• W2757383585 hasConcept C42219234 @default.
• W2757383585 hasConcept C519063684 @default.
• W2757383585 hasConcept C71924100 @default.
• W2757383585 hasConcept C83974742 @default.
• W2757383585 hasConcept C98274493 @default.
• W2757383585 hasConceptScore W2757383585C126322002 @default.
• W2757383585 hasConceptScore W2757383585C131783052 @default.
• W2757383585 hasConceptScore W2757383585C134018914 @default.
• W2757383585 hasConceptScore W2757383585C170493617 @default.
• W2757383585 hasConceptScore W2757383585C185592680 @default.
• W2757383585 hasConceptScore W2757383585C2776175493 @default.
• W2757383585 hasConceptScore W2757383585C2776885963 @default.
• W2757383585 hasConceptScore W2757383585C2778409475 @default.
• W2757383585 hasConceptScore W2757383585C2778500429 @default.
• W2757383585 hasConceptScore W2757383585C2780795376 @default.
• W2757383585 hasConceptScore W2757383585C2781460320 @default.
• W2757383585 hasConceptScore W2757383585C42219234 @default.
• W2757383585 hasConceptScore W2757383585C519063684 @default.
• W2757383585 hasConceptScore W2757383585C71924100 @default.
• W2757383585 hasConceptScore W2757383585C83974742 @default.
• W2757383585 hasConceptScore W2757383585C98274493 @default.
• W2757383585 hasFunder F4320321473 @default.
• W2757383585 hasLocation W27573835851 @default.
• W2757383585 hasOpenAccess W2757383585 @default.
• W2757383585 hasPrimaryLocation W27573835851 @default.
• W2757383585 hasRelatedWork W1484899758 @default.
• W2757383585 hasRelatedWork W1967841507 @default.
• W2757383585 hasRelatedWork W1970313683 @default.
• W2757383585 hasRelatedWork W1981320574 @default.
• W2757383585 hasRelatedWork W1984671860 @default.
• W2757383585 hasRelatedWork W1991162026 @default.
• W2757383585 hasRelatedWork W2014229148 @default.
• W2757383585 hasRelatedWork W2036503945 @default.
• W2757383585 hasRelatedWork W2040172536 @default.
• W2757383585 hasRelatedWork W2043067657 @default.
• W2757383585 hasRelatedWork W2087898899 @default.
• W2757383585 hasRelatedWork W2189588046 @default.
• W2757383585 hasRelatedWork W2401361643 @default.

• next