Matches in SemOpenAlex for { <https://semopenalex.org/work/W2757390360> ?p ?o ?g. }
- W2757390360 endingPage "888" @default.
- W2757390360 startingPage "871" @default.
- W2757390360 abstract "Carbon nanotube (CNT) is a nanomaterial that has received interest because of its high-tensile strength and low weight. Although CNTs differ substantially in physico-chemical properties, they share high aspect ratio which resembles that of asbestos and other fibers causing lung cancer and mesothelioma. One type of multi-walled CNTs (i.e. MWCNT-7) has been classified as possibly carcinogenic to humans by IARC (Group 2B) based on experimental animal data, whereas other types of MWCNTs and single-walled CNTs (SWCNT) could not be classified due to lack of data from epidemiologic studies and insufficient mechanistic evidence. Damage to DNA is considered to be a key mechanistic step in the development of fiber-induced cancer. Thus, the genotoxic potential can be a cornerstone in the evaluation of hazards of CNTs. The present study used a weight of evidence (WoE) analysis to evaluate the genotoxicity of different types of CNTs. Genotoxicity endpoints close to cancer (mutations and chromosome aberrations) and animal models had highest weight in the WoE analysis. Eight CNT materials out of 130, which had been assessed in several studies, were evaluated in the WoE analysis. The results demonstrated that MWCNT-7 has strongest WoE for a genotoxic hazard among the MWCNTs. Two types of SWCNTs have a similar WoE for genotoxicity as MWCNT-7. Several reference materials from the Joint Research Centre have less WoE for genotoxicity. The WoE analysis demonstrates a difference in genotoxicity for CNTs, but further research is required to unravel the physico-chemical characteristics that govern the differences in genotoxic hazard." @default.
- W2757390360 created "2017-10-06" @default.
- W2757390360 creator A5021170936 @default.
- W2757390360 creator A5054957111 @default.
- W2757390360 date "2017-09-22" @default.
- W2757390360 modified "2023-10-16" @default.
- W2757390360 title "Weight of evidence analysis for assessing the genotoxic potential of carbon nanotubes" @default.
- W2757390360 cites W1552620600 @default.
- W2757390360 cites W1561086229 @default.
- W2757390360 cites W1563116824 @default.
- W2757390360 cites W1888660086 @default.
- W2757390360 cites W1905949689 @default.
- W2757390360 cites W1906935673 @default.
- W2757390360 cites W1907554865 @default.
- W2757390360 cites W1932931543 @default.
- W2757390360 cites W1963698113 @default.
- W2757390360 cites W1965480509 @default.
- W2757390360 cites W1967331918 @default.
- W2757390360 cites W1973914781 @default.
- W2757390360 cites W1975059364 @default.
- W2757390360 cites W1976270051 @default.
- W2757390360 cites W1984458677 @default.
- W2757390360 cites W1987232784 @default.
- W2757390360 cites W1988829860 @default.
- W2757390360 cites W1989103032 @default.
- W2757390360 cites W2004472671 @default.
- W2757390360 cites W2010276640 @default.
- W2757390360 cites W2011168240 @default.
- W2757390360 cites W2011707607 @default.
- W2757390360 cites W2015788990 @default.
- W2757390360 cites W2016299851 @default.
- W2757390360 cites W2024481637 @default.
- W2757390360 cites W2039246310 @default.
- W2757390360 cites W2043548074 @default.
- W2757390360 cites W2044789903 @default.
- W2757390360 cites W2045462515 @default.
- W2757390360 cites W2045978507 @default.
- W2757390360 cites W2047986756 @default.
- W2757390360 cites W2048456951 @default.
- W2757390360 cites W2050083788 @default.
- W2757390360 cites W2050106802 @default.
- W2757390360 cites W2063638086 @default.
- W2757390360 cites W2072131879 @default.
- W2757390360 cites W2072760187 @default.
- W2757390360 cites W2072843401 @default.
- W2757390360 cites W2075072883 @default.
- W2757390360 cites W2076113630 @default.
- W2757390360 cites W2078420680 @default.
- W2757390360 cites W2080513830 @default.
- W2757390360 cites W2081377625 @default.
- W2757390360 cites W2086822315 @default.
- W2757390360 cites W2087330734 @default.
- W2757390360 cites W2090517253 @default.
- W2757390360 cites W2097663396 @default.
- W2757390360 cites W2098038825 @default.
- W2757390360 cites W2102244990 @default.
- W2757390360 cites W2105052446 @default.
- W2757390360 cites W2105425505 @default.
- W2757390360 cites W2109358360 @default.
- W2757390360 cites W2111878168 @default.
- W2757390360 cites W2112844455 @default.
- W2757390360 cites W2119538646 @default.
- W2757390360 cites W2124961458 @default.
- W2757390360 cites W2126902508 @default.
- W2757390360 cites W2129779488 @default.
- W2757390360 cites W2130491881 @default.
- W2757390360 cites W2137199462 @default.
- W2757390360 cites W2138042860 @default.
- W2757390360 cites W2138249971 @default.
- W2757390360 cites W2140036981 @default.
- W2757390360 cites W2140897409 @default.
- W2757390360 cites W2152162417 @default.
- W2757390360 cites W2152314477 @default.
- W2757390360 cites W2156408048 @default.
- W2757390360 cites W2156827867 @default.
- W2757390360 cites W2160634660 @default.
- W2757390360 cites W2160863106 @default.
- W2757390360 cites W2161940948 @default.
- W2757390360 cites W2171741011 @default.
- W2757390360 cites W2180765816 @default.
- W2757390360 cites W2186578978 @default.
- W2757390360 cites W2206377354 @default.
- W2757390360 cites W2207306432 @default.
- W2757390360 cites W2222400423 @default.
- W2757390360 cites W2254058479 @default.
- W2757390360 cites W2313305133 @default.
- W2757390360 cites W2314601975 @default.
- W2757390360 cites W2338883795 @default.
- W2757390360 cites W2400025420 @default.
- W2757390360 cites W2463738079 @default.
- W2757390360 cites W2507870118 @default.
- W2757390360 cites W2514718028 @default.
- W2757390360 cites W2517028335 @default.
- W2757390360 cites W2517591559 @default.
- W2757390360 cites W2527857188 @default.
- W2757390360 cites W2528019607 @default.
- W2757390360 cites W2528342077 @default.
- W2757390360 cites W2531341616 @default.