FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2757490488> ?p ?o ?g. }

• W2757490488 endingPage "684" @default.
• W2757490488 startingPage "674" @default.
• W2757490488 abstract "BackgroundWe used functional connectivity measures from brain resting state functional magnetic resonance imaging to identify human neural correlates of sedation with dexmedetomidine or propofol and their similarities with natural sleep.MethodsConnectivity within the resting state networks that are proposed to sustain consciousness generation was compared between deep non-rapid-eye-movement (N3) sleep, dexmedetomidine sedation, and propofol sedation in volunteers who became unresponsive to verbal command. A newly acquired dexmedetomidine dataset was compared with our previously published propofol and N3 sleep datasets.ResultsIn all three unresponsive states (dexmedetomidine sedation, propofol sedation, and N3 sleep), within-network functional connectivity, including thalamic functional connectivity in the higher-order (default mode, executive control, and salience) networks, was significantly reduced as compared with the wake state. Thalamic functional connectivity was not reduced for unresponsive states within lower-order (auditory, sensorimotor, and visual) networks. Voxel-wise statistical comparisons between the different unresponsive states revealed that thalamic functional connectivity with the medial prefrontal/anterior cingulate cortex and with the mesopontine area was reduced least during dexmedetomidine-induced unresponsiveness and most during propofol-induced unresponsiveness. The reduction seen during N3 sleep was intermediate between those of dexmedetomidine and propofol.ConclusionsThalamic connectivity with key nodes of arousal and saliency detection networks was relatively preserved during N3 sleep and dexmedetomidine-induced unresponsiveness as compared to propofol. These network effects may explain the rapid recovery of oriented responsiveness to external stimulation seen under dexmedetomidine sedation.Trial registry numberCommittee number: ‘Comité d’Ethique Hospitalo-Facultaire Universitaire de Liège’ (707); EudraCT number: 2012-003562-40; internal reference: 20121/135; accepted on August 31, 2012; Chair: Prof G. Rorive. As it was considered a phase I clinical trial, this protocol does not appear on the EudraCT public website." @default.
• W2757490488 created "2017-10-06" @default.
• W2757490488 creator A5009690578 @default.
• W2757490488 creator A5010711385 @default.
• W2757490488 creator A5024625204 @default.
• W2757490488 creator A5036299315 @default.
• W2757490488 creator A5040646480 @default.
• W2757490488 creator A5040720948 @default.
• W2757490488 creator A5042265881 @default.
• W2757490488 creator A5043876590 @default.
• W2757490488 creator A5058591723 @default.
• W2757490488 creator A5061379701 @default.
• W2757490488 creator A5062003959 @default.
• W2757490488 creator A5072188433 @default.
• W2757490488 creator A5087491861 @default.
• W2757490488 creator A5088346225 @default.
• W2757490488 date "2017-10-01" @default.
• W2757490488 modified "2023-10-14" @default.
• W2757490488 title "Brain functional connectivity differentiates dexmedetomidine from propofol and natural sleep" @default.
• W2757490488 cites W1525081124 @default.
• W2757490488 cites W1596614913 @default.
• W2757490488 cites W1887777875 @default.
• W2757490488 cites W1950544107 @default.
• W2757490488 cites W1971355925 @default.
• W2757490488 cites W1972669888 @default.
• W2757490488 cites W1973669500 @default.
• W2757490488 cites W1985408596 @default.
• W2757490488 cites W1988881714 @default.
• W2757490488 cites W2002702421 @default.
• W2757490488 cites W2002923643 @default.
• W2757490488 cites W2017573472 @default.
• W2757490488 cites W2022746025 @default.
• W2757490488 cites W2025829561 @default.
• W2757490488 cites W2033340861 @default.
• W2757490488 cites W2047189453 @default.
• W2757490488 cites W2048265343 @default.
• W2757490488 cites W2056306065 @default.
• W2757490488 cites W2072202815 @default.
• W2757490488 cites W2088267315 @default.
• W2757490488 cites W2088396389 @default.
• W2757490488 cites W2090957966 @default.
• W2757490488 cites W2107508491 @default.
• W2757490488 cites W2107632000 @default.
• W2757490488 cites W2110729317 @default.
• W2757490488 cites W2112639978 @default.
• W2757490488 cites W2115826426 @default.
• W2757490488 cites W2116658855 @default.
• W2757490488 cites W2126155630 @default.
• W2757490488 cites W2126602481 @default.
• W2757490488 cites W2129624700 @default.
• W2757490488 cites W2132693675 @default.
• W2757490488 cites W2133903921 @default.
• W2757490488 cites W2149745827 @default.
• W2757490488 cites W2150967988 @default.
• W2757490488 cites W2157339062 @default.
• W2757490488 cites W2161794281 @default.
• W2757490488 cites W2169345238 @default.
• W2757490488 cites W2178122306 @default.
• W2757490488 cites W2212776331 @default.
• W2757490488 cites W2515708122 @default.
• W2757490488 cites W2518058704 @default.
• W2757490488 cites W4237872303 @default.
• W2757490488 doi "https://doi.org/10.1093/bja/aex257" @default.
• W2757490488 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29121293" @default.
• W2757490488 hasPublicationYear "2017" @default.
• W2757490488 type Work @default.
• W2757490488 sameAs 2757490488 @default.
• W2757490488 citedByCount "79" @default.
• W2757490488 countsByYear W27574904882017 @default.
• W2757490488 countsByYear W27574904882018 @default.
• W2757490488 countsByYear W27574904882019 @default.
• W2757490488 countsByYear W27574904882020 @default.
• W2757490488 countsByYear W27574904882021 @default.
• W2757490488 countsByYear W27574904882022 @default.
• W2757490488 countsByYear W27574904882023 @default.
• W2757490488 crossrefType "journal-article" @default.
• W2757490488 hasAuthorship W2757490488A5009690578 @default.
• W2757490488 hasAuthorship W2757490488A5010711385 @default.
• W2757490488 hasAuthorship W2757490488A5024625204 @default.
• W2757490488 hasAuthorship W2757490488A5036299315 @default.
• W2757490488 hasAuthorship W2757490488A5040646480 @default.
• W2757490488 hasAuthorship W2757490488A5040720948 @default.
• W2757490488 hasAuthorship W2757490488A5042265881 @default.
• W2757490488 hasAuthorship W2757490488A5043876590 @default.
• W2757490488 hasAuthorship W2757490488A5058591723 @default.
• W2757490488 hasAuthorship W2757490488A5061379701 @default.
• W2757490488 hasAuthorship W2757490488A5062003959 @default.
• W2757490488 hasAuthorship W2757490488A5072188433 @default.
• W2757490488 hasAuthorship W2757490488A5087491861 @default.
• W2757490488 hasAuthorship W2757490488A5088346225 @default.
• W2757490488 hasBestOaLocation W27574904881 @default.
• W2757490488 hasConcept C129564537 @default.
• W2757490488 hasConcept C141516989 @default.
• W2757490488 hasConcept C15744967 @default.
• W2757490488 hasConcept C169760540 @default.
• W2757490488 hasConcept C169900460 @default.
• W2757490488 hasConcept C2776277131 @default.
• W2757490488 hasConcept C2776470351 @default.

• next