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• W2757492402 abstract "MicroRNAs (miRNAs) have been reported to be regulated in different ways in a variety of liver diseases. As a key modulator of cellular function in both innate and adaptive immunity, the role of miR-155 in chronic hepatitis B virus (HBV) infection remains largely unknown. Here, we investigated the expression and function of miR-155 in chronic hepatitis B (CHB) patients. It was found that miR-155 expression in peripheral blood mononuclear cells (PBMC) was lower in CHB patients than healthy controls (HC). Among CHB infection, immune-active (IA) patients with abnormal ALT levels had relatively higher miR-155 expression in PBMCs and serum than immune-tolerant carriers, but were comparable to inactive carriers. Moreover, there was a positive correlation between miR-155 expression and ALT levels in CHB patients. Particularly, miR-155 expression in NK cells was significantly down-regulated in IA patients compared with HC. Inversely, SOCS1, a target of miR-155, was up-regulated in NK cells of IA patients. Overexpression of miR-155 in NK cells from IA patients led to a decrease in SOCS1 expression and an increase of IFN-γ production. Finally, accompanied by the normalization of ALT, miR-155 expression in PBMC gradually decreased during telbivudine or peg-IFN-α-2a therapy. Interestingly, higher miR-155 expression at baseline was associated with better response to telbivudine therapy, but not peg-IFN-α-2a. In conclusion, our data suggested that miR-155 down-regulation in NK cells of IA patients impaired IFN-γ production by targeting SOCS1, which may contribute to immune dysfunction during CHB infection. Additionally, baseline miR-155 expression could predict the treatment response to telbivudine therapy." @default.
• W2757492402 created "2017-10-06" @default.
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• W2757492402 date "2017-09-22" @default.
• W2757492402 modified "2023-10-17" @default.
• W2757492402 title "Lower Expression of MicroRNA-155 Contributes to Dysfunction of Natural Killer Cells in Patients with Chronic Hepatitis B" @default.
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• W2757492402 doi "https://doi.org/10.3389/fimmu.2017.01173" @default.
• W2757492402 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5614978" @default.
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• W2757492402 hasPublicationYear "2017" @default.
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