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- W2757579087 abstract "Abstract A causal relationship between congenital Zika virus (ZIKV) exposure and microcephaly and other neurological disorders have been established, but long-term consequences of infection are still unknown. We evaluated acute and late neuropathological and behavioral consequences of ZIKV infection in a neonatal immunocompetent mouse model. ZIKV showed brain tropism, causing post-natal microcephaly and several behavioral dysfunctions. During the acute phase of infection, mice developed very frequent epileptic seizures, which are consistently reduced by TNF-α neutralization. Although adult animals recover from seizures, they become more susceptible to chemically-induced crises. Intriguingly, the virus remained actively replicating in adult animals, which show persistent necrosis and calcifications in the mice brain. Altogether the results reveal late consequences of neonatal ZIKV exposure and suggest the early inhibition of neuroinflammation as a potential treatment." @default.
- W2757579087 created "2017-10-06" @default.
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- W2757579087 date "2017-09-28" @default.
- W2757579087 modified "2023-10-01" @default.
- W2757579087 title "Neonatal Zika virus infection causes epileptic seizures, viral persistence and long-term behavioral impairment" @default.
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- W2757579087 doi "https://doi.org/10.1101/195172" @default.
- W2757579087 hasPublicationYear "2017" @default.
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