Matches in SemOpenAlex for { <https://semopenalex.org/work/W2757618533> ?p ?o ?g. }
- W2757618533 abstract "Abstract This study used isotope-coded protein label (ICPL) quantitative proteomics and bioinformatics analysis to examine changes in vitreous protein content and associated pathways during lens-induced eye growth. First, the vitreous protein profile of normal 7-day old chicks was characterized by nano-liquid chromatography electrospray ionization tandem mass spectrometry. A total of 341 unique proteins were identified. Next, myopia and hyperopia were induced in the same chick by attaching −10D lenses to the right eye and +10D lenses to the left eye, for 3 and 7 days. Protein expression in lens-induced ametropic eyes was analyzed using the ICPL approach coupled to LCMS. Four proteins (cystatin, apolipoprotein A1, ovotransferrin, and purpurin) were significantly up-regulated in the vitreous after 3 days of wearing −10D lenses relative to +10D lens contralateral eyes. The differences in protein expression were less pronounced after 7 days when the eyes approached full compensation. In a different group of chicks, western blot confirmed the up-regulation of apolipoprotein A1 and ovotransferrin in the myopic vitreous relative to both contralateral lens-free eyes and hyperopic eyes in separate animals wearing +10D lenses. Bioinformatics analysis suggested oxidative stress and lipid metabolism as pathways involved in compensated ocular elongation." @default.
- W2757618533 created "2017-10-06" @default.
- W2757618533 creator A5006019895 @default.
- W2757618533 creator A5013406104 @default.
- W2757618533 creator A5030764102 @default.
- W2757618533 creator A5033485428 @default.
- W2757618533 creator A5036359505 @default.
- W2757618533 creator A5053710949 @default.
- W2757618533 creator A5075359816 @default.
- W2757618533 date "2017-10-04" @default.
- W2757618533 modified "2023-09-27" @default.
- W2757618533 title "Isotope-coded protein label based quantitative proteomic analysis reveals significant up-regulation of apolipoprotein A1 and ovotransferrin in the myopic chick vitreous" @default.
- W2757618533 cites W12061760 @default.
- W2757618533 cites W1506199975 @default.
- W2757618533 cites W1567722340 @default.
- W2757618533 cites W1605129913 @default.
- W2757618533 cites W1632753381 @default.
- W2757618533 cites W1740306729 @default.
- W2757618533 cites W1749867637 @default.
- W2757618533 cites W183439287 @default.
- W2757618533 cites W1847403331 @default.
- W2757618533 cites W1855379264 @default.
- W2757618533 cites W1930333410 @default.
- W2757618533 cites W1963989169 @default.
- W2757618533 cites W1965144335 @default.
- W2757618533 cites W1965917470 @default.
- W2757618533 cites W196793732 @default.
- W2757618533 cites W1968611669 @default.
- W2757618533 cites W1970356840 @default.
- W2757618533 cites W1971979121 @default.
- W2757618533 cites W1972126075 @default.
- W2757618533 cites W1974004836 @default.
- W2757618533 cites W1988406020 @default.
- W2757618533 cites W1988861479 @default.
- W2757618533 cites W1989361398 @default.
- W2757618533 cites W1996121046 @default.
- W2757618533 cites W1999497297 @default.
- W2757618533 cites W2000908347 @default.
- W2757618533 cites W2004838889 @default.
- W2757618533 cites W2006288979 @default.
- W2757618533 cites W2010394020 @default.
- W2757618533 cites W2011265611 @default.
- W2757618533 cites W2014620589 @default.
- W2757618533 cites W2018757293 @default.
- W2757618533 cites W2019426766 @default.
- W2757618533 cites W2021814263 @default.
- W2757618533 cites W2024174176 @default.
- W2757618533 cites W2024297705 @default.
- W2757618533 cites W2037952434 @default.
- W2757618533 cites W2041647848 @default.
- W2757618533 cites W2052900838 @default.
- W2757618533 cites W2056044165 @default.
- W2757618533 cites W2061683842 @default.
- W2757618533 cites W2064766975 @default.
- W2757618533 cites W2065641828 @default.
- W2757618533 cites W2068939714 @default.
- W2757618533 cites W2072351646 @default.
- W2757618533 cites W2074669560 @default.
- W2757618533 cites W2075683938 @default.
- W2757618533 cites W2076600548 @default.
- W2757618533 cites W2078271476 @default.
- W2757618533 cites W2081697692 @default.
- W2757618533 cites W2083718441 @default.
- W2757618533 cites W2087131933 @default.
- W2757618533 cites W2087256228 @default.
- W2757618533 cites W2087440467 @default.
- W2757618533 cites W2089703911 @default.
- W2757618533 cites W2094939529 @default.
- W2757618533 cites W2104443284 @default.
- W2757618533 cites W2105071475 @default.
- W2757618533 cites W2110370370 @default.
- W2757618533 cites W2110521150 @default.
- W2757618533 cites W2115211076 @default.
- W2757618533 cites W2117327695 @default.
- W2757618533 cites W2121777623 @default.
- W2757618533 cites W2123962756 @default.
- W2757618533 cites W2129476237 @default.
- W2757618533 cites W2129605330 @default.
- W2757618533 cites W2144286979 @default.
- W2757618533 cites W2164518567 @default.
- W2757618533 cites W2166817088 @default.
- W2757618533 cites W2169120674 @default.
- W2757618533 cites W2258238112 @default.
- W2757618533 cites W2288052737 @default.
- W2757618533 cites W2319953529 @default.
- W2757618533 cites W2335711157 @default.
- W2757618533 cites W2394973123 @default.
- W2757618533 cites W2469138161 @default.
- W2757618533 cites W2472238533 @default.
- W2757618533 cites W2510702952 @default.
- W2757618533 cites W295589262 @default.
- W2757618533 cites W385732249 @default.
- W2757618533 cites W4233312985 @default.
- W2757618533 cites W4292964442 @default.
- W2757618533 doi "https://doi.org/10.1038/s41598-017-12650-7" @default.
- W2757618533 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5627271" @default.
- W2757618533 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28978931" @default.
- W2757618533 hasPublicationYear "2017" @default.
- W2757618533 type Work @default.
- W2757618533 sameAs 2757618533 @default.