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• W2757658411 endingPage "230" @default.
• W2757658411 startingPage "217" @default.
• W2757658411 abstract "Abstract Objective: Clinical trials in menopause have undergone much scrutiny over the years. This has led to significant shifts in the treatment of symptomatic menopause and a substantial impact on women. We aim to delineate the key studies contributing to this controversy and highlight new directions specifically related to menopausal hormone therapy (HT) and vascular disease risk. Methods: We performed a search of sentinel studies delineating the risks and benefits of HT in otherwise healthy postmenopausal women. Using PubMed we input the following search terms: hormone replacement therapy, cardiovascular disease, coronary artery disease, coronary atherosclerosis, myocardial infarction, angina, coronary heart calcification, carotid intimal thickness, lipids, and/or lipoproteins. We included studies of menopausal women (surgical or natural) using combined estrogen/progestogen therapy or estrogen-only therapy that looked at cardiovascular disease risk factors or outcomes. Studies were evaluated for inclusion by the authors; however, this is not intended to be a systematic or an exhaustive analysis. Results: In women close to the time of menopause, there is a decreased risk of subclinical and clinical coronary heart disease with menopausal HT. Additionally, HT confers a significant benefit to vasomotor symptoms of menopause, bone health, and colorectal cancer. There is an increased risk of venous thromboembolism with oral formulations that appears mitigated with transdermal estradiol. Mixed data regarding breast cancer risk are available, with some studies suggesting an increased risk of invasive breast cancer with estrogen/progestogen therapy and a null effect with estrogen-only therapy. Other more long-term epidemiologic studies identify a decreased risk. Conclusions: The available literature suggests that HT is a viable option for the primary prevention of cardiovascular disease in postmenopausal women. Newer trials will likely verify this assessment. If this is enough to change clinical practice, however, remains to be seen given the general fear of HT by many with prescriptive authority, and also the women in our care." @default.
• W2757658411 created "2017-10-06" @default.
• W2757658411 creator A5066194821 @default.
• W2757658411 creator A5079180373 @default.
• W2757658411 date "2018-02-01" @default.
• W2757658411 modified "2023-09-27" @default.
• W2757658411 title "Clinical trials in menopause" @default.
• W2757658411 cites W1487388658 @default.
• W2757658411 cites W1586699954 @default.
• W2757658411 cites W1593442063 @default.
• W2757658411 cites W1833241730 @default.
• W2757658411 cites W1854193697 @default.
• W2757658411 cites W1904672210 @default.
• W2757658411 cites W1927817986 @default.
• W2757658411 cites W1964911444 @default.
• W2757658411 cites W1970590644 @default.
• W2757658411 cites W1976113748 @default.
• W2757658411 cites W1980766143 @default.
• W2757658411 cites W1982032419 @default.
• W2757658411 cites W1985722848 @default.
• W2757658411 cites W1985785776 @default.
• W2757658411 cites W1986330330 @default.
• W2757658411 cites W1986569933 @default.
• W2757658411 cites W1987017833 @default.
• W2757658411 cites W1988374735 @default.
• W2757658411 cites W1988860947 @default.
• W2757658411 cites W1990817648 @default.
• W2757658411 cites W1995802267 @default.
• W2757658411 cites W1999018690 @default.
• W2757658411 cites W2000410035 @default.
• W2757658411 cites W2000836832 @default.
• W2757658411 cites W2002573431 @default.
• W2757658411 cites W2007841512 @default.
• W2757658411 cites W2007872498 @default.
• W2757658411 cites W2009249344 @default.
• W2757658411 cites W2010330048 @default.
• W2757658411 cites W2010601385 @default.
• W2757658411 cites W2011861966 @default.
• W2757658411 cites W2012994483 @default.
• W2757658411 cites W2015015990 @default.
• W2757658411 cites W2016746678 @default.
• W2757658411 cites W2018611651 @default.
• W2757658411 cites W2021137215 @default.
• W2757658411 cites W2021715911 @default.
• W2757658411 cites W2023072905 @default.
• W2757658411 cites W2023110657 @default.
• W2757658411 cites W2027154527 @default.
• W2757658411 cites W2031570803 @default.
• W2757658411 cites W2032431489 @default.
• W2757658411 cites W2033028209 @default.
• W2757658411 cites W2034243341 @default.
• W2757658411 cites W2035045876 @default.
• W2757658411 cites W2037269240 @default.
• W2757658411 cites W2039535075 @default.
• W2757658411 cites W2042072599 @default.
• W2757658411 cites W2047172236 @default.
• W2757658411 cites W2049413564 @default.
• W2757658411 cites W2050592411 @default.
• W2757658411 cites W2051034159 @default.
• W2757658411 cites W2051086756 @default.
• W2757658411 cites W2053593143 @default.
• W2757658411 cites W2054782822 @default.
• W2757658411 cites W2059542059 @default.
• W2757658411 cites W2060775470 @default.
• W2757658411 cites W2062359643 @default.
• W2757658411 cites W2063031738 @default.
• W2757658411 cites W2065253130 @default.
• W2757658411 cites W2067590949 @default.
• W2757658411 cites W2070500804 @default.
• W2757658411 cites W2070660975 @default.
• W2757658411 cites W2073902078 @default.
• W2757658411 cites W2078308971 @default.
• W2757658411 cites W2078878902 @default.
• W2757658411 cites W2084682522 @default.
• W2757658411 cites W2085207465 @default.
• W2757658411 cites W2087034766 @default.
• W2757658411 cites W2087841827 @default.
• W2757658411 cites W2089358310 @default.
• W2757658411 cites W2091159054 @default.
• W2757658411 cites W2091232445 @default.
• W2757658411 cites W2091647434 @default.
• W2757658411 cites W2096913799 @default.
• W2757658411 cites W2097867305 @default.
• W2757658411 cites W2098663481 @default.
• W2757658411 cites W2098850229 @default.
• W2757658411 cites W2099501873 @default.
• W2757658411 cites W2101153384 @default.
• W2757658411 cites W2103263838 @default.
• W2757658411 cites W2103604769 @default.
• W2757658411 cites W2103732396 @default.
• W2757658411 cites W2105351124 @default.
• W2757658411 cites W2107604419 @default.
• W2757658411 cites W2109803507 @default.
• W2757658411 cites W2110388554 @default.
• W2757658411 cites W2110683897 @default.
• W2757658411 cites W2110885050 @default.
• W2757658411 cites W2112061209 @default.
• W2757658411 cites W2112442316 @default.

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