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- W2757703359 endingPage "357" @default.
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- W2757703359 abstract "Cigarette smoking causes many human diseases including cardiovascular disease, lung disease and cancer. Novel tobacco products with reduced yields of toxicants compared to cigarettes, such as tobacco-heating products, snus and electronic cigarettes, hold great potential for reducing the harms associated with tobacco use. In the UK several public health agencies have advocated a potential role for novel products in tobacco harm reduction. Public Health England has stated that The current best estimate is that e-cigarettes are around 95% less harmful than smoking and the Royal College of Physicians has urged public health to Promote e-cigarettes widely as substitute for smoking. Health related claims on novel products such as 'reduced exposure' and 'reduced risk' should be substantiated using a weight of evidence approach based on a comprehensive scientific assessment. The US FDA, has provided draft guidance outlining a framework to assess novel products as Modified Risk Tobacco Products (MRTP). Based on this, we now propose a framework comprising pre-clinical, clinical, and population studies to assess the risk profile of novel tobacco products. Additionally, the utility of this framework is assessed through the pre-clinical and part of the clinical comparison of a commercial e-cigarette (Vype ePen) with a scientific reference cigarette (3R4F) and the results of these studies suggest that ePen has the potential to be a reduced risk product." @default.
- W2757703359 created "2017-10-06" @default.
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- W2757703359 date "2017-11-01" @default.
- W2757703359 modified "2023-09-29" @default.
- W2757703359 title "Assessing modified risk tobacco and nicotine products: Description of the scientific framework and assessment of a closed modular electronic cigarette" @default.
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- W2757703359 doi "https://doi.org/10.1016/j.yrtph.2017.09.008" @default.
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- W2757703359 hasPublicationYear "2017" @default.
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