FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2757830069> ?p ?o ?g. }

• W2757830069 endingPage "E724" @default.
• W2757830069 startingPage "E723" @default.
• W2757830069 abstract "Standard inverse planning techniques scatter dose throughout organs at risk to reach a favorable distribution. However variable volume organs (VVO), like the rectum, are subject to variations in daily filling and the dose delivered may not reflect the dose planned. We investigate gradient optimization (GO) as a method of improving rectal dose distribution compared to traditional dose-volume criteria during prostate radiation planning. A volumetric modulated arc therapy plan prescribing 79.2Gy in 1.8Gy per fraction was created for ten patients with localized prostate cancer using target coverage goals and dose constraints for rectum, bladder, and penile bulb (PB), as specified in RTOG 0815. The planning target volume (PTV) was defined as the prostate and proximal 1cm of the seminal vesicles with a 5mm margin. Normal structures were contoured per RTOG guidelines. A second plan was created using two additional optimization structures: 1) Rectum-(PTV+5mm) and 2) Rectum-(PTV+9mm). These were given a maximum point dose limit of 49Gy and 35Gy, respectively. The maximum prostate dose (Dmax), rectal (V75, V70, V65, V60), bladder (V80, V75, V70, V65) and mean PB doses were extracted from both plans and compared. The distance from the 100% to 50% and 50Gy isodose lines (IDL) was measured on an axial slice at the mid-PTV level and compared. In all 20 plans, > 98% of the PTV received prescription dose and all normal structures were within RTOG specified dose constraints. All rectal parameters were lower for the GO plan than the standard plan. Rectal V75, V70 and gradients are summarized in Table 1. The GO approach can on average achieve a dose fall off from 79.2Gy to 50Gy in 0.7cm compared to 2.1cm with standard methods (p=0.0003). There was no statistically significant difference in Dmax, bladder, or penile bulb doses. Our data suggests that GO techniques can produce superior rectal dose distributions without compromising PTV coverage and other organs at risk. Combining GO techniques with upcoming technologies such as rectal spacers could dramatically improve the potential for escalating prostate doses with external beam. Furthermore, GO plans can be tested and applied to other VVO.Abstract 3721; Table 1Comparing dosimetric parameters between standard and gradient optimized (GO) plansStandard Plan Mean (SD)GO Plan Mean (SD)Mean Difference (SD)p-valueRectumV75Gy (%)9.66 (+3.66)5.54 (+1.96)4.12 (+2.10)0.0002V70Gy (%)13.88 (+4.49)7.37 (+2.29)6.50 (+3.04)<0.0001V60Gy (%)23.40 (+6.69)10.76 (+2.90)11.24 (+4.32)<0.0001Distance from 100% to 50% IDL posteriorly (cm)3.39 (+1.28)0.98 (+0.18)2.42 (+1.35)0.0003Distance from Prescription dose to 50Gy posteriorly (cm)2.06 (+0.75)0.68 (+0.12)1.38 (+0.78)0.0003 Open table in a new tab" @default.
• W2757830069 created "2017-10-06" @default.
• W2757830069 creator A5005712788 @default.
• W2757830069 creator A5034301588 @default.
• W2757830069 creator A5056257547 @default.
• W2757830069 creator A5076590888 @default.
• W2757830069 creator A5080211712 @default.
• W2757830069 date "2017-10-01" @default.
• W2757830069 modified "2023-10-16" @default.
• W2757830069 title "Using Gradient Optimization in Place of Volumetric Constraints to Improve Rectal Dose Distribution During Dose-Escalated Radiation Therapy Planning for Prostate Cancer" @default.
• W2757830069 doi "https://doi.org/10.1016/j.ijrobp.2017.06.2343" @default.
• W2757830069 hasPublicationYear "2017" @default.
• W2757830069 type Work @default.
• W2757830069 sameAs 2757830069 @default.
• W2757830069 citedByCount "1" @default.
• W2757830069 countsByYear W27578300692020 @default.
• W2757830069 crossrefType "journal-article" @default.
• W2757830069 hasAuthorship W2757830069A5005712788 @default.
• W2757830069 hasAuthorship W2757830069A5034301588 @default.
• W2757830069 hasAuthorship W2757830069A5056257547 @default.
• W2757830069 hasAuthorship W2757830069A5076590888 @default.
• W2757830069 hasAuthorship W2757830069A5080211712 @default.
• W2757830069 hasBestOaLocation W27578300691 @default.
• W2757830069 hasConcept C121608353 @default.
• W2757830069 hasConcept C126322002 @default.
• W2757830069 hasConcept C126838900 @default.
• W2757830069 hasConcept C141071460 @default.
• W2757830069 hasConcept C201645570 @default.
• W2757830069 hasConcept C2776235491 @default.
• W2757830069 hasConcept C2780192828 @default.
• W2757830069 hasConcept C2781074409 @default.
• W2757830069 hasConcept C2989005 @default.
• W2757830069 hasConcept C509974204 @default.
• W2757830069 hasConcept C71924100 @default.
• W2757830069 hasConceptScore W2757830069C121608353 @default.
• W2757830069 hasConceptScore W2757830069C126322002 @default.
• W2757830069 hasConceptScore W2757830069C126838900 @default.
• W2757830069 hasConceptScore W2757830069C141071460 @default.
• W2757830069 hasConceptScore W2757830069C201645570 @default.
• W2757830069 hasConceptScore W2757830069C2776235491 @default.
• W2757830069 hasConceptScore W2757830069C2780192828 @default.
• W2757830069 hasConceptScore W2757830069C2781074409 @default.
• W2757830069 hasConceptScore W2757830069C2989005 @default.
• W2757830069 hasConceptScore W2757830069C509974204 @default.
• W2757830069 hasConceptScore W2757830069C71924100 @default.
• W2757830069 hasIssue "2" @default.
• W2757830069 hasLocation W27578300691 @default.
• W2757830069 hasOpenAccess W2757830069 @default.
• W2757830069 hasPrimaryLocation W27578300691 @default.
• W2757830069 hasRelatedWork W1965767437 @default.
• W2757830069 hasRelatedWork W1971464107 @default.
• W2757830069 hasRelatedWork W1987445093 @default.
• W2757830069 hasRelatedWork W2000483113 @default.
• W2757830069 hasRelatedWork W2008116431 @default.
• W2757830069 hasRelatedWork W2028320337 @default.
• W2757830069 hasRelatedWork W2049593891 @default.
• W2757830069 hasRelatedWork W2066875539 @default.
• W2757830069 hasRelatedWork W2072225115 @default.
• W2757830069 hasRelatedWork W3032252569 @default.
• W2757830069 hasVolume "99" @default.
• W2757830069 isParatext "false" @default.
• W2757830069 isRetracted "false" @default.
• W2757830069 magId "2757830069" @default.
• W2757830069 workType "article" @default.