FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2757938365> ?p ?o ?g. }

• W2757938365 endingPage "85" @default.
• W2757938365 startingPage "77" @default.
• W2757938365 abstract "Human cell-based approaches to assess defined key events in allergic contact dermatitis (ACD) are well-established, but lack cutaneous penetration and biotransformation as well as cellular cross-talk. Herein, we integrated in vitro-generated immature MUTZ-3-derived Langerhans-like cells (MUTZ-LCs) or monocyte-derived LC-like cells (MoLCs) into reconstructed human skin (RHS), consistent of a stratified epidermis formed by primary keratinocytes on a dermal compartment with collagen-embedded primary fibroblasts. LC-like cells were mainly localized in the epidermal compartment and distributed homogenously in accordance with native human skin. Topical application of the strong contact sensitizer 2,4-dinitrochlorobenzene (DNCB) induced IL-6 and IL-8 secretion in RHS with LC-like cells, whereas no change was observed in reference models. Increased gene expression of CD83, PD-L1, and CXCR4 in the dermal compartment indicated LC maturation. Importantly, exposure to DNCB enhanced mobility of the LC-like cells from epidermal to dermal compartments. In response to the moderate sensitizer isoeugenol and irritant sodium dodecyl sulphate, the obtained response was less pronounced. In summary, we integrated immature and functional MUTZ-LCs and MoLCs into RHS and provide a unique comparative experimental setting to monitor early events during skin sensitization." @default.
• W2757938365 created "2017-10-06" @default.
• W2757938365 creator A5010206513 @default.
• W2757938365 creator A5031360585 @default.
• W2757938365 creator A5036280790 @default.
• W2757938365 creator A5038260736 @default.
• W2757938365 creator A5054344650 @default.
• W2757938365 creator A5054345692 @default.
• W2757938365 date "2018-02-01" @default.
• W2757938365 modified "2023-10-12" @default.
• W2757938365 title "Characterization of reconstructed human skin containing Langerhans cells to monitor molecular events in skin sensitization" @default.
• W2757938365 cites W1246201870 @default.
• W2757938365 cites W1481065751 @default.
• W2757938365 cites W1932984089 @default.
• W2757938365 cites W1965659294 @default.
• W2757938365 cites W1966327639 @default.
• W2757938365 cites W1969260205 @default.
• W2757938365 cites W1971821266 @default.
• W2757938365 cites W1973442022 @default.
• W2757938365 cites W1976477992 @default.
• W2757938365 cites W1982160212 @default.
• W2757938365 cites W1991465136 @default.
• W2757938365 cites W1992541969 @default.
• W2757938365 cites W1994574230 @default.
• W2757938365 cites W2008806781 @default.
• W2757938365 cites W2012416479 @default.
• W2757938365 cites W2024871860 @default.
• W2757938365 cites W2025276497 @default.
• W2757938365 cites W2048339949 @default.
• W2757938365 cites W2051457107 @default.
• W2757938365 cites W2056147498 @default.
• W2757938365 cites W2071290289 @default.
• W2757938365 cites W2073092958 @default.
• W2757938365 cites W2087356545 @default.
• W2757938365 cites W2087747552 @default.
• W2757938365 cites W2089721863 @default.
• W2757938365 cites W2090560199 @default.
• W2757938365 cites W2092028991 @default.
• W2757938365 cites W2092894443 @default.
• W2757938365 cites W2095272963 @default.
• W2757938365 cites W2099574567 @default.
• W2757938365 cites W2111128415 @default.
• W2757938365 cites W2118954538 @default.
• W2757938365 cites W2128208383 @default.
• W2757938365 cites W2128232832 @default.
• W2757938365 cites W2142256464 @default.
• W2757938365 cites W2143916596 @default.
• W2757938365 cites W2154764366 @default.
• W2757938365 cites W2158164157 @default.
• W2757938365 cites W2169672731 @default.
• W2757938365 cites W2171005142 @default.
• W2757938365 cites W2248881641 @default.
• W2757938365 cites W226525109 @default.
• W2757938365 cites W2280060444 @default.
• W2757938365 cites W2322475913 @default.
• W2757938365 cites W2342399216 @default.
• W2757938365 cites W2507779780 @default.
• W2757938365 cites W2599489246 @default.
• W2757938365 cites W27495970 @default.
• W2757938365 cites W366325714 @default.
• W2757938365 doi "https://doi.org/10.1016/j.tiv.2017.09.019" @default.
• W2757938365 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28941582" @default.
• W2757938365 hasPublicationYear "2018" @default.
• W2757938365 type Work @default.
• W2757938365 sameAs 2757938365 @default.
• W2757938365 citedByCount "20" @default.
• W2757938365 countsByYear W27579383652018 @default.
• W2757938365 countsByYear W27579383652019 @default.
• W2757938365 countsByYear W27579383652020 @default.
• W2757938365 countsByYear W27579383652021 @default.
• W2757938365 countsByYear W27579383652022 @default.
• W2757938365 countsByYear W27579383652023 @default.
• W2757938365 crossrefType "journal-article" @default.
• W2757938365 hasAuthorship W2757938365A5010206513 @default.
• W2757938365 hasAuthorship W2757938365A5031360585 @default.
• W2757938365 hasAuthorship W2757938365A5036280790 @default.
• W2757938365 hasAuthorship W2757938365A5038260736 @default.
• W2757938365 hasAuthorship W2757938365A5054344650 @default.
• W2757938365 hasAuthorship W2757938365A5054345692 @default.
• W2757938365 hasConcept C105702510 @default.
• W2757938365 hasConcept C185592680 @default.
• W2757938365 hasConcept C202751555 @default.
• W2757938365 hasConcept C203014093 @default.
• W2757938365 hasConcept C207480886 @default.
• W2757938365 hasConcept C2776056826 @default.
• W2757938365 hasConcept C2776217527 @default.
• W2757938365 hasConcept C2776458125 @default.
• W2757938365 hasConcept C2777459323 @default.
• W2757938365 hasConcept C2778379841 @default.
• W2757938365 hasConcept C2778833550 @default.
• W2757938365 hasConcept C54355233 @default.
• W2757938365 hasConcept C55493867 @default.
• W2757938365 hasConcept C86803240 @default.
• W2757938365 hasConcept C8891405 @default.
• W2757938365 hasConcept C95444343 @default.
• W2757938365 hasConceptScore W2757938365C105702510 @default.
• W2757938365 hasConceptScore W2757938365C185592680 @default.
• W2757938365 hasConceptScore W2757938365C202751555 @default.

• next