FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2757949543> ?p ?o ?g. }

• W2757949543 abstract "Macrophages are central to inflammatory response and become polarized towards the M1 or M2 states upon activation by immunostimulants. In this study, we investigated the effects of lipopolysaccharides (LPS) and interleukin (IL)-17A on the activation of macrophages in in vivo mouse skin. We examined whether macrophages are activated in the skin of imiquimod (IMQ)-treated mice, a model for IL-17A-induced psoriasis-like skin inflammation, and flaky-tail (Flg ft ) mice, a model for IL-17A-induced chronic atopic dermatitis-like skin inflammation. LPS and IL-17A independently increased the expression levels of iNOS, CX3CR1, CD206, phospho-STAT1 and phospho-STAT3 proteins in the skin of B6 mice, and the effects of LPS was not altered by IL-17A. The expression levels of these proteins were increased in the skin of IMQ-treated and Flg ft mice. IL-17A neutralization increased the expressions of iNOS and phospho-STAT1 in the IMQ-treated skin, but it decreased the expressions of CD206 and phospho-STAT3 proteins in the skin of Flg ft mice, suggesting that macrophages to change from the M2 to the M1 state in the skin of these mice. These results suggest that IL-17A is involved in the activation of macrophages that are in the process of adopting the heterogeneous profiles of both the M1 and M2 states." @default.
• W2757949543 created "2017-10-06" @default.
• W2757949543 creator A5003863619 @default.
• W2757949543 creator A5012123010 @default.
• W2757949543 creator A5019921899 @default.
• W2757949543 creator A5022986744 @default.
• W2757949543 creator A5032649284 @default.
• W2757949543 creator A5045386047 @default.
• W2757949543 creator A5047106223 @default.
• W2757949543 creator A5052252431 @default.
• W2757949543 creator A5057625356 @default.
• W2757949543 creator A5070641442 @default.
• W2757949543 date "2017-09-29" @default.
• W2757949543 modified "2023-10-15" @default.
• W2757949543 title "IL-17A induces heterogeneous macrophages, and it does not alter the effects of lipopolysaccharides on macrophage activation in the skin of mice" @default.
• W2757949543 cites W1740603564 @default.
• W2757949543 cites W1939997832 @default.
• W2757949543 cites W1978432820 @default.
• W2757949543 cites W1978768695 @default.
• W2757949543 cites W1982673677 @default.
• W2757949543 cites W1983260461 @default.
• W2757949543 cites W1991160853 @default.
• W2757949543 cites W1991658642 @default.
• W2757949543 cites W2008479676 @default.
• W2757949543 cites W2026526625 @default.
• W2757949543 cites W2038689279 @default.
• W2757949543 cites W2046388159 @default.
• W2757949543 cites W2054472394 @default.
• W2757949543 cites W2055252232 @default.
• W2757949543 cites W2055580813 @default.
• W2757949543 cites W2058863496 @default.
• W2757949543 cites W2060527543 @default.
• W2757949543 cites W2065871536 @default.
• W2757949543 cites W2066396134 @default.
• W2757949543 cites W2070855360 @default.
• W2757949543 cites W2078206843 @default.
• W2757949543 cites W2082921049 @default.
• W2757949543 cites W2088931562 @default.
• W2757949543 cites W2093308972 @default.
• W2757949543 cites W2093949724 @default.
• W2757949543 cites W2102370935 @default.
• W2757949543 cites W2116537360 @default.
• W2757949543 cites W2129638048 @default.
• W2757949543 cites W2131310374 @default.
• W2757949543 cites W2131462541 @default.
• W2757949543 cites W2133449490 @default.
• W2757949543 cites W2140264128 @default.
• W2757949543 cites W2145634436 @default.
• W2757949543 cites W2158282912 @default.
• W2757949543 cites W2172089049 @default.
• W2757949543 cites W2242565786 @default.
• W2757949543 cites W2276012049 @default.
• W2757949543 cites W2291416076 @default.
• W2757949543 cites W2515817940 @default.
• W2757949543 cites W86026435 @default.
• W2757949543 doi "https://doi.org/10.1038/s41598-017-12756-y" @default.
• W2757949543 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5622065" @default.
• W2757949543 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28963556" @default.
• W2757949543 hasPublicationYear "2017" @default.
• W2757949543 type Work @default.
• W2757949543 sameAs 2757949543 @default.
• W2757949543 citedByCount "33" @default.
• W2757949543 countsByYear W27579495432018 @default.
• W2757949543 countsByYear W27579495432019 @default.
• W2757949543 countsByYear W27579495432020 @default.
• W2757949543 countsByYear W27579495432021 @default.
• W2757949543 countsByYear W27579495432022 @default.
• W2757949543 countsByYear W27579495432023 @default.
• W2757949543 crossrefType "journal-article" @default.
• W2757949543 hasAuthorship W2757949543A5003863619 @default.
• W2757949543 hasAuthorship W2757949543A5012123010 @default.
• W2757949543 hasAuthorship W2757949543A5019921899 @default.
• W2757949543 hasAuthorship W2757949543A5022986744 @default.
• W2757949543 hasAuthorship W2757949543A5032649284 @default.
• W2757949543 hasAuthorship W2757949543A5045386047 @default.
• W2757949543 hasAuthorship W2757949543A5047106223 @default.
• W2757949543 hasAuthorship W2757949543A5052252431 @default.
• W2757949543 hasAuthorship W2757949543A5057625356 @default.
• W2757949543 hasAuthorship W2757949543A5070641442 @default.
• W2757949543 hasBestOaLocation W27579495431 @default.
• W2757949543 hasConcept C11960822 @default.
• W2757949543 hasConcept C12823836 @default.
• W2757949543 hasConcept C13373296 @default.
• W2757949543 hasConcept C150903083 @default.
• W2757949543 hasConcept C185592680 @default.
• W2757949543 hasConcept C202751555 @default.
• W2757949543 hasConcept C203014093 @default.
• W2757949543 hasConcept C207001950 @default.
• W2757949543 hasConcept C2776914184 @default.
• W2757949543 hasConcept C2778329239 @default.
• W2757949543 hasConcept C2778754761 @default.
• W2757949543 hasConcept C2778923194 @default.
• W2757949543 hasConcept C2779112978 @default.
• W2757949543 hasConcept C2779244956 @default.
• W2757949543 hasConcept C2780564577 @default.
• W2757949543 hasConcept C31179232 @default.
• W2757949543 hasConcept C47348012 @default.
• W2757949543 hasConcept C55493867 @default.
• W2757949543 hasConcept C71924100 @default.
• W2757949543 hasConcept C86803240 @default.

• next