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- W2758091881 abstract "This review deeply addresses for the first time the diversity, regulation and mechanisms leading to mutational overexpression of intrinsic β-lactamases from non-fermenting and other non-Enterobacteriaceae Gram-negative opportunistic pathogens. After a general overview of the intrinsic β-lactamases described so far in these microorganisms, including circa. 60 species and 100 different enzymes, we review the wide array of regulatory pathways of these β-lactamases. They include diverse LysR-type regulators, which control the expression of β-lactamases from relevant nosocomial pathogens such as Pseudomonas aeruginosa or Stenothrophomonas maltophilia or two-component regulators, with special relevance in Aeromonas spp., along with other pathways. Likewise, the multiple mutational mechanisms leading to β-lactamase overexpression and β-lactam resistance development, including AmpD (N-acetyl-muramyl-L-alanine amidase), DacB (PBP4), MrcA (PPBP1A) and other PBPs, BlrAB (two-component regulator) or several lytic transglycosylases among others, are also described. Moreover, we address the growing evidence of a major interplay between β-lactamase regulation, peptidoglycan metabolism and virulence. Finally, we analyse recent works showing that blocking of peptidoglycan recycling (such as inhibition of NagZ or AmpG) might be useful to prevent and revert β-lactam resistance. Altogether, the provided information and the identified gaps should be valuable for guiding future strategies for combating multidrug-resistant Gram-negative pathogens." @default.
- W2758091881 created "2017-10-06" @default.
- W2758091881 creator A5021213940 @default.
- W2758091881 creator A5042508206 @default.
- W2758091881 creator A5077919558 @default.
- W2758091881 date "2017-09-22" @default.
- W2758091881 modified "2023-10-14" @default.
- W2758091881 title "Diversity and regulation of intrinsic β-lactamases from non-fermenting and other Gram-negative opportunistic pathogens" @default.
- W2758091881 cites W1481398414 @default.
- W2758091881 cites W1520993259 @default.
- W2758091881 cites W1529182844 @default.
- W2758091881 cites W1534451622 @default.
- W2758091881 cites W1535444764 @default.
- W2758091881 cites W1541586888 @default.
- W2758091881 cites W1548036406 @default.
- W2758091881 cites W1576608645 @default.
- W2758091881 cites W1601691180 @default.
- W2758091881 cites W1649027544 @default.
- W2758091881 cites W1765884813 @default.
- W2758091881 cites W1782662424 @default.
- W2758091881 cites W1823010904 @default.
- W2758091881 cites W1825991320 @default.
- W2758091881 cites W1850659291 @default.
- W2758091881 cites W1879027467 @default.
- W2758091881 cites W1903485778 @default.
- W2758091881 cites W1909122772 @default.
- W2758091881 cites W1920890130 @default.
- W2758091881 cites W1922548901 @default.
- W2758091881 cites W1924975182 @default.
- W2758091881 cites W1936029280 @default.
- W2758091881 cites W1955596595 @default.
- W2758091881 cites W1959513603 @default.
- W2758091881 cites W1964017011 @default.
- W2758091881 cites W1965536046 @default.
- W2758091881 cites W1966944924 @default.
- W2758091881 cites W1967312581 @default.
- W2758091881 cites W1971927293 @default.
- W2758091881 cites W1972570534 @default.
- W2758091881 cites W1972751539 @default.
- W2758091881 cites W1972946308 @default.
- W2758091881 cites W1974885234 @default.
- W2758091881 cites W1977222141 @default.
- W2758091881 cites W1977900754 @default.
- W2758091881 cites W1979995952 @default.
- W2758091881 cites W1980145079 @default.
- W2758091881 cites W1983825379 @default.
- W2758091881 cites W1983890715 @default.
- W2758091881 cites W1984654391 @default.
- W2758091881 cites W1986597981 @default.
- W2758091881 cites W1987369590 @default.
- W2758091881 cites W19889520 @default.
- W2758091881 cites W1989559075 @default.
- W2758091881 cites W1994855421 @default.
- W2758091881 cites W1996660418 @default.
- W2758091881 cites W1997736352 @default.
- W2758091881 cites W2000673837 @default.
- W2758091881 cites W2001164465 @default.
- W2758091881 cites W2001460255 @default.
- W2758091881 cites W2001608349 @default.
- W2758091881 cites W2002045810 @default.
- W2758091881 cites W2002679883 @default.
- W2758091881 cites W2003634035 @default.
- W2758091881 cites W2004195474 @default.
- W2758091881 cites W2005099180 @default.
- W2758091881 cites W2005600183 @default.
- W2758091881 cites W2008436709 @default.
- W2758091881 cites W2008686307 @default.
- W2758091881 cites W2012866410 @default.
- W2758091881 cites W2013974039 @default.
- W2758091881 cites W2014088092 @default.
- W2758091881 cites W2014724586 @default.
- W2758091881 cites W2014857872 @default.
- W2758091881 cites W2017115870 @default.
- W2758091881 cites W2017941781 @default.
- W2758091881 cites W2018404965 @default.
- W2758091881 cites W2019655319 @default.
- W2758091881 cites W2020622909 @default.
- W2758091881 cites W2021434900 @default.
- W2758091881 cites W2021853773 @default.
- W2758091881 cites W2023316078 @default.
- W2758091881 cites W2024287671 @default.
- W2758091881 cites W2026659552 @default.
- W2758091881 cites W2028347256 @default.
- W2758091881 cites W2030338103 @default.
- W2758091881 cites W2030368239 @default.
- W2758091881 cites W2030831262 @default.
- W2758091881 cites W2030878378 @default.
- W2758091881 cites W2031141462 @default.
- W2758091881 cites W2032363136 @default.
- W2758091881 cites W2033164689 @default.
- W2758091881 cites W2034383178 @default.
- W2758091881 cites W2034443922 @default.
- W2758091881 cites W2037429250 @default.
- W2758091881 cites W2037685605 @default.
- W2758091881 cites W2037876790 @default.
- W2758091881 cites W2040883911 @default.
- W2758091881 cites W2041093210 @default.
- W2758091881 cites W2043014602 @default.