Matches in SemOpenAlex for { <https://semopenalex.org/work/W2758110609> ?p ?o ?g. }
- W2758110609 abstract "Although bone morphogenetic protein 9 (BMP9) is highly capable of promoting the osteogenic differentiation of mesenchymal stem cells (MSCs) both in vitro and in vivo, the molecular mechanisms involved remain to be fully elucidated. Runt-related transcription factor (RUNX)3 is an essential regulator of osteoblast/chondrocyte maturation. However, the exact role of RUNX3 in BMP9 osteoinductive activity is unknown. In this study, we sought to investigate the functional role of RUNX3 in the BMP9-induced osteogenic differentiation of MSCs. We found that BMP9 upregulated the endogenous expression of RUNX3 in MSCs. The overexpression or/and knockdown of RUNX3 both increased the levels of alkaline phosphatase (ALP) a marker of BMP9-induced early osteogenic differentiation. Nevertheless, matrix mineralization, a marker of BMP9-induced late osteogenic differentiation was enhanced by the overexpression of RUNX3, whereas it was inhibited by the knockdown of RUNX3. The BMP9-induced expression of osteogenic pivotal transcription factors [inhibitor of differentiation (Id)3, distal-less homeobox 5 (DLX5) and RUNX2)] was further increased by the overexpression of RUNX3; however, it was reduced by the knockdown of RUNX3. However, the expression levels of Id1 and Id2 were both enhanced by the overexpression or/and knockdown of RUNX3. The BMP9-induced phosphorylation of Smad1/5/8 was increased with the overexpression of RUNX3, and yet was decreased with the knockdown of RUNX3. Collectively, our findings suggest that RUNX3 is an essential modulator of the BMP9-induced osteoblast lineage differentiation of MSCs." @default.
- W2758110609 created "2017-10-06" @default.
- W2758110609 creator A5027475930 @default.
- W2758110609 creator A5031234889 @default.
- W2758110609 creator A5032926098 @default.
- W2758110609 creator A5065956038 @default.
- W2758110609 creator A5083650954 @default.
- W2758110609 creator A5085465774 @default.
- W2758110609 date "2017-09-27" @default.
- W2758110609 modified "2023-10-10" @default.
- W2758110609 title "RUNX3 plays an important role in mediating the BMP9-induced osteogenic differentiation of mesenchymal stem cells" @default.
- W2758110609 cites W1499883890 @default.
- W2758110609 cites W1850369921 @default.
- W2758110609 cites W1939946462 @default.
- W2758110609 cites W1965698106 @default.
- W2758110609 cites W1969408413 @default.
- W2758110609 cites W1975426375 @default.
- W2758110609 cites W1984959227 @default.
- W2758110609 cites W1989157416 @default.
- W2758110609 cites W1989618386 @default.
- W2758110609 cites W1990196985 @default.
- W2758110609 cites W1991164124 @default.
- W2758110609 cites W1991766825 @default.
- W2758110609 cites W1993907854 @default.
- W2758110609 cites W1996371854 @default.
- W2758110609 cites W1997812904 @default.
- W2758110609 cites W1998786833 @default.
- W2758110609 cites W2010446781 @default.
- W2758110609 cites W2012994555 @default.
- W2758110609 cites W2016727307 @default.
- W2758110609 cites W2025046506 @default.
- W2758110609 cites W2034023141 @default.
- W2758110609 cites W2034312402 @default.
- W2758110609 cites W2034779933 @default.
- W2758110609 cites W2035219492 @default.
- W2758110609 cites W2038988633 @default.
- W2758110609 cites W2040121303 @default.
- W2758110609 cites W2040814514 @default.
- W2758110609 cites W2043281974 @default.
- W2758110609 cites W2051578118 @default.
- W2758110609 cites W2058821062 @default.
- W2758110609 cites W2064708319 @default.
- W2758110609 cites W2069667907 @default.
- W2758110609 cites W2075484345 @default.
- W2758110609 cites W2077620451 @default.
- W2758110609 cites W2077665432 @default.
- W2758110609 cites W2086054038 @default.
- W2758110609 cites W2089817924 @default.
- W2758110609 cites W2093854662 @default.
- W2758110609 cites W2094698627 @default.
- W2758110609 cites W2112274246 @default.
- W2758110609 cites W2114239412 @default.
- W2758110609 cites W2116668498 @default.
- W2758110609 cites W2118717300 @default.
- W2758110609 cites W2122433264 @default.
- W2758110609 cites W2132051926 @default.
- W2758110609 cites W2132877445 @default.
- W2758110609 cites W2145305383 @default.
- W2758110609 cites W2151238232 @default.
- W2758110609 cites W2160284674 @default.
- W2758110609 cites W2220158883 @default.
- W2758110609 cites W4253422011 @default.
- W2758110609 doi "https://doi.org/10.3892/ijmm.2017.3155" @default.
- W2758110609 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29039519" @default.
- W2758110609 hasPublicationYear "2017" @default.
- W2758110609 type Work @default.
- W2758110609 sameAs 2758110609 @default.
- W2758110609 citedByCount "18" @default.
- W2758110609 countsByYear W27581106092018 @default.
- W2758110609 countsByYear W27581106092019 @default.
- W2758110609 countsByYear W27581106092020 @default.
- W2758110609 countsByYear W27581106092021 @default.
- W2758110609 countsByYear W27581106092022 @default.
- W2758110609 countsByYear W27581106092023 @default.
- W2758110609 crossrefType "journal-article" @default.
- W2758110609 hasAuthorship W2758110609A5027475930 @default.
- W2758110609 hasAuthorship W2758110609A5031234889 @default.
- W2758110609 hasAuthorship W2758110609A5032926098 @default.
- W2758110609 hasAuthorship W2758110609A5065956038 @default.
- W2758110609 hasAuthorship W2758110609A5083650954 @default.
- W2758110609 hasAuthorship W2758110609A5085465774 @default.
- W2758110609 hasBestOaLocation W27581106091 @default.
- W2758110609 hasConcept C104317684 @default.
- W2758110609 hasConcept C127561419 @default.
- W2758110609 hasConcept C148738053 @default.
- W2758110609 hasConcept C153911025 @default.
- W2758110609 hasConcept C160160445 @default.
- W2758110609 hasConcept C173396325 @default.
- W2758110609 hasConcept C181199279 @default.
- W2758110609 hasConcept C185592680 @default.
- W2758110609 hasConcept C190283241 @default.
- W2758110609 hasConcept C198826908 @default.
- W2758110609 hasConcept C202751555 @default.
- W2758110609 hasConcept C2776363554 @default.
- W2758110609 hasConcept C2778260815 @default.
- W2758110609 hasConcept C502942594 @default.
- W2758110609 hasConcept C55493867 @default.
- W2758110609 hasConcept C86339819 @default.
- W2758110609 hasConcept C86803240 @default.
- W2758110609 hasConcept C95444343 @default.