Matches in SemOpenAlex for { <https://semopenalex.org/work/W2758162615> ?p ?o ?g. }
Showing items 1 to 81 of
81
with 100 items per page.
- W2758162615 endingPage "E341" @default.
- W2758162615 startingPage "E341" @default.
- W2758162615 abstract "To develop and validate a radiomics signature for prediction of early local failure in patients with hypopharyngeal squamous cell carcinoma (HPSCC) receiving organ preservation therapy (OPT). We used least absolute shrinkage and selection operator (LASSO) regression model to select and develop the radiomics signature derived from 801 radiomics features which were extracted by analyzing visualized primary tumors on T2-weighted and non-contrast / contrast enhanced T1-weighted magnetic resonance imaging (MRI) images of a primary cohort enrolling 92 patients with HPSCC from January 2003 to April 2010. An independent validation cohort containing 25 consecutive patients from May 2009 to December 2014 was used to confirm the prediction performance of the identified radiomics signature. Univariate and multivariate analysis were further performed using logistic regression and cox regression model to compare the performance for predicting the 1-year local control and overall survival with several potential prognostic factors, including age, gender, radiomics signature, clinical TMN stage, smoking and alcohol behavior. The radiomics signature, consisting of 17 image features, performed well in prediction of 1 year HPSCC local control both in the primary cohort and validation cohort. The areas under the curve of the receiver operating characteristic curve calculated using the radiomics signature were 0.846 and 0.780, respectively. The best cut-off point of radiomics signature score for predicitng local control in the entire cohort is 0.27, with the sensitivity, specificity, and accuracy of 60.7%, 97.4%, and 0.79, respectively. The univariate and multivariate analysis revealed only clinical nodal stage (HR: 5.6; p = 0.024) and radiomics signature score more than 0.27 (HR: 21.3; p<0.001) as significant predictors for 1 year local failure, whereas only radiomics signature more than 0.27 (HR: 2.663; p<0.001) as a significant factor for overall survival. Our results indicate that a radiomics signature according to quantitative image analysis of MRI is a novel and useful approach for predicting early local failure in HPSCC patients who received OPT. This new approach will help us select the optimal treatment modality for HPSCC patients." @default.
- W2758162615 created "2017-10-06" @default.
- W2758162615 creator A5015847499 @default.
- W2758162615 creator A5017859553 @default.
- W2758162615 creator A5089675435 @default.
- W2758162615 date "2017-10-01" @default.
- W2758162615 modified "2023-09-25" @default.
- W2758162615 title "Development and Validation of a Radiomics Signature for Predicting Early Local Failure After Organ Preservation Treatment of Hypopharyngeal Cancer" @default.
- W2758162615 doi "https://doi.org/10.1016/j.ijrobp.2017.06.1416" @default.
- W2758162615 hasPublicationYear "2017" @default.
- W2758162615 type Work @default.
- W2758162615 sameAs 2758162615 @default.
- W2758162615 citedByCount "0" @default.
- W2758162615 crossrefType "journal-article" @default.
- W2758162615 hasAuthorship W2758162615A5015847499 @default.
- W2758162615 hasAuthorship W2758162615A5017859553 @default.
- W2758162615 hasAuthorship W2758162615A5089675435 @default.
- W2758162615 hasBestOaLocation W27581626151 @default.
- W2758162615 hasConcept C119857082 @default.
- W2758162615 hasConcept C126322002 @default.
- W2758162615 hasConcept C126838900 @default.
- W2758162615 hasConcept C136764020 @default.
- W2758162615 hasConcept C143409427 @default.
- W2758162615 hasConcept C143998085 @default.
- W2758162615 hasConcept C144301174 @default.
- W2758162615 hasConcept C146357865 @default.
- W2758162615 hasConcept C151730666 @default.
- W2758162615 hasConcept C151956035 @default.
- W2758162615 hasConcept C161584116 @default.
- W2758162615 hasConcept C199163554 @default.
- W2758162615 hasConcept C2778559731 @default.
- W2758162615 hasConcept C37616216 @default.
- W2758162615 hasConcept C38180746 @default.
- W2758162615 hasConcept C41008148 @default.
- W2758162615 hasConcept C50382708 @default.
- W2758162615 hasConcept C58471807 @default.
- W2758162615 hasConcept C71924100 @default.
- W2758162615 hasConcept C72563966 @default.
- W2758162615 hasConcept C86803240 @default.
- W2758162615 hasConceptScore W2758162615C119857082 @default.
- W2758162615 hasConceptScore W2758162615C126322002 @default.
- W2758162615 hasConceptScore W2758162615C126838900 @default.
- W2758162615 hasConceptScore W2758162615C136764020 @default.
- W2758162615 hasConceptScore W2758162615C143409427 @default.
- W2758162615 hasConceptScore W2758162615C143998085 @default.
- W2758162615 hasConceptScore W2758162615C144301174 @default.
- W2758162615 hasConceptScore W2758162615C146357865 @default.
- W2758162615 hasConceptScore W2758162615C151730666 @default.
- W2758162615 hasConceptScore W2758162615C151956035 @default.
- W2758162615 hasConceptScore W2758162615C161584116 @default.
- W2758162615 hasConceptScore W2758162615C199163554 @default.
- W2758162615 hasConceptScore W2758162615C2778559731 @default.
- W2758162615 hasConceptScore W2758162615C37616216 @default.
- W2758162615 hasConceptScore W2758162615C38180746 @default.
- W2758162615 hasConceptScore W2758162615C41008148 @default.
- W2758162615 hasConceptScore W2758162615C50382708 @default.
- W2758162615 hasConceptScore W2758162615C58471807 @default.
- W2758162615 hasConceptScore W2758162615C71924100 @default.
- W2758162615 hasConceptScore W2758162615C72563966 @default.
- W2758162615 hasConceptScore W2758162615C86803240 @default.
- W2758162615 hasIssue "2" @default.
- W2758162615 hasLocation W27581626151 @default.
- W2758162615 hasOpenAccess W2758162615 @default.
- W2758162615 hasPrimaryLocation W27581626151 @default.
- W2758162615 hasRelatedWork W2082153206 @default.
- W2758162615 hasRelatedWork W2361144647 @default.
- W2758162615 hasRelatedWork W3049619988 @default.
- W2758162615 hasRelatedWork W3123311962 @default.
- W2758162615 hasRelatedWork W3200895526 @default.
- W2758162615 hasRelatedWork W4205198487 @default.
- W2758162615 hasRelatedWork W4292454933 @default.
- W2758162615 hasRelatedWork W4313494932 @default.
- W2758162615 hasRelatedWork W4323364109 @default.
- W2758162615 hasRelatedWork W4361918880 @default.
- W2758162615 hasVolume "99" @default.
- W2758162615 isParatext "false" @default.
- W2758162615 isRetracted "false" @default.
- W2758162615 magId "2758162615" @default.
- W2758162615 workType "article" @default.