FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2758176523> ?p ?o ?g. }

• W2758176523 endingPage "181" @default.
• W2758176523 startingPage "174" @default.
• W2758176523 abstract "Purpose We aimed to study radiation-induced gene expression changes and to identify differences in gene expression between patients with and without response to radiation therapy (RT) for invasive breast cancer with the purpose of exploring whether a predictive signature could be developed. Such a signature could assist in optimizing individualized locoregional treatment. Methods and Materials RNA-seq using next-generation sequencing was performed on fresh frozen samples from pretreatment biopsies and post-RT surgery specimens from patients with low-risk breast cancer treated within the multicenter preoperative accelerated partial breast irradiation trial. Patients were treated with preoperative RT (10 × 4 Gy in 10 days or 5 × 6 Gy in 5 days) and a lumpectomy 6 weeks thereafter. The response of the tumor to RT was evaluated by pathologic assessment. To analyze the gene expression data, unsupervised and supervised clustering was performed. Gene expression profiles were compared between biopsies of responders and nonresponders and between samples before and after RT. Results Ninety-four samples from 77 patients were analyzed: 68 pretreatment biopsies and 26 post-RT surgery specimens. Six patients had a (near) complete pathologic response, 3 patients had a good response, 32 patients had a partial response, and 22 patients had no or very limited response. Comparing patients with and without response to RT, 25 genes were significantly differentially expressed and were not linked to a pathway. Comparison of samples before and after RT identified significant changes in gene expression. Genes involved in p53 signaling, TNFA1 signaling, apoptosis, epithelial mesenchymal transition, and inflammatory response were upregulated. Genes involved in mitotic spindle, G2M checkpoint, and E2F targets were downregulated. Conclusions Radiation-induced gene expression changes mainly involved p53 signaling, cell cycle regulation, DNA repair, and inflammatory response. No clinically significant differences could be identified in gene expression between patients with and without response to RT. We aimed to study radiation-induced gene expression changes and to identify differences in gene expression between patients with and without response to radiation therapy (RT) for invasive breast cancer with the purpose of exploring whether a predictive signature could be developed. Such a signature could assist in optimizing individualized locoregional treatment. RNA-seq using next-generation sequencing was performed on fresh frozen samples from pretreatment biopsies and post-RT surgery specimens from patients with low-risk breast cancer treated within the multicenter preoperative accelerated partial breast irradiation trial. Patients were treated with preoperative RT (10 × 4 Gy in 10 days or 5 × 6 Gy in 5 days) and a lumpectomy 6 weeks thereafter. The response of the tumor to RT was evaluated by pathologic assessment. To analyze the gene expression data, unsupervised and supervised clustering was performed. Gene expression profiles were compared between biopsies of responders and nonresponders and between samples before and after RT. Ninety-four samples from 77 patients were analyzed: 68 pretreatment biopsies and 26 post-RT surgery specimens. Six patients had a (near) complete pathologic response, 3 patients had a good response, 32 patients had a partial response, and 22 patients had no or very limited response. Comparing patients with and without response to RT, 25 genes were significantly differentially expressed and were not linked to a pathway. Comparison of samples before and after RT identified significant changes in gene expression. Genes involved in p53 signaling, TNFA1 signaling, apoptosis, epithelial mesenchymal transition, and inflammatory response were upregulated. Genes involved in mitotic spindle, G2M checkpoint, and E2F targets were downregulated. Radiation-induced gene expression changes mainly involved p53 signaling, cell cycle regulation, DNA repair, and inflammatory response. No clinically significant differences could be identified in gene expression between patients with and without response to RT." @default.
• W2758176523 created "2017-10-06" @default.
• W2758176523 creator A5016632019 @default.
• W2758176523 creator A5020517461 @default.
• W2758176523 creator A5046853252 @default.
• W2758176523 creator A5050409251 @default.
• W2758176523 creator A5056304256 @default.
• W2758176523 creator A5062981502 @default.
• W2758176523 creator A5063757732 @default.
• W2758176523 creator A5068893119 @default.
• W2758176523 creator A5069816630 @default.
• W2758176523 creator A5076006564 @default.
• W2758176523 creator A5089839279 @default.
• W2758176523 date "2020-01-01" @default.
• W2758176523 modified "2023-10-01" @default.
• W2758176523 title "Response to Preoperative Radiation Therapy in Relation to Gene Expression Patterns in Breast Cancer Patients" @default.
• W2758176523 cites W1912124796 @default.
• W2758176523 cites W1964524427 @default.
• W2758176523 cites W1982585549 @default.
• W2758176523 cites W2003748401 @default.
• W2758176523 cites W2010059019 @default.
• W2758176523 cites W2013797350 @default.
• W2758176523 cites W2023494838 @default.
• W2758176523 cites W2032894034 @default.
• W2758176523 cites W2045945802 @default.
• W2758176523 cites W2086960359 @default.
• W2758176523 cites W2096301110 @default.
• W2758176523 cites W2097065948 @default.
• W2758176523 cites W2097255042 @default.
• W2758176523 cites W2100025800 @default.
• W2758176523 cites W2108905728 @default.
• W2758176523 cites W2110480159 @default.
• W2758176523 cites W2122446147 @default.
• W2758176523 cites W2133264822 @default.
• W2758176523 cites W2134526812 @default.
• W2758176523 cites W2139763823 @default.
• W2758176523 cites W2144293828 @default.
• W2758176523 cites W2151236279 @default.
• W2758176523 cites W2165877571 @default.
• W2758176523 cites W2167353413 @default.
• W2758176523 cites W2170122339 @default.
• W2758176523 cites W2171015116 @default.
• W2758176523 cites W2179438025 @default.
• W2758176523 cites W2214074259 @default.
• W2758176523 cites W2263577673 @default.
• W2758176523 cites W2555240095 @default.
• W2758176523 cites W2593021861 @default.
• W2758176523 cites W2742020913 @default.
• W2758176523 cites W2770903587 @default.
• W2758176523 cites W2796102911 @default.
• W2758176523 cites W2809151576 @default.
• W2758176523 cites W2810905056 @default.
• W2758176523 doi "https://doi.org/10.1016/j.ijrobp.2019.09.002" @default.
• W2758176523 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31525407" @default.
• W2758176523 hasPublicationYear "2020" @default.
• W2758176523 type Work @default.
• W2758176523 sameAs 2758176523 @default.
• W2758176523 citedByCount "16" @default.
• W2758176523 countsByYear W27581765232020 @default.
• W2758176523 countsByYear W27581765232021 @default.
• W2758176523 countsByYear W27581765232022 @default.
• W2758176523 countsByYear W27581765232023 @default.
• W2758176523 crossrefType "journal-article" @default.
• W2758176523 hasAuthorship W2758176523A5016632019 @default.
• W2758176523 hasAuthorship W2758176523A5020517461 @default.
• W2758176523 hasAuthorship W2758176523A5046853252 @default.
• W2758176523 hasAuthorship W2758176523A5050409251 @default.
• W2758176523 hasAuthorship W2758176523A5056304256 @default.
• W2758176523 hasAuthorship W2758176523A5062981502 @default.
• W2758176523 hasAuthorship W2758176523A5063757732 @default.
• W2758176523 hasAuthorship W2758176523A5068893119 @default.
• W2758176523 hasAuthorship W2758176523A5069816630 @default.
• W2758176523 hasAuthorship W2758176523A5076006564 @default.
• W2758176523 hasAuthorship W2758176523A5089839279 @default.
• W2758176523 hasConcept C104317684 @default.
• W2758176523 hasConcept C121608353 @default.
• W2758176523 hasConcept C126322002 @default.
• W2758176523 hasConcept C142724271 @default.
• W2758176523 hasConcept C143998085 @default.
• W2758176523 hasConcept C150194340 @default.
• W2758176523 hasConcept C185592680 @default.
• W2758176523 hasConcept C2775934546 @default.
• W2758176523 hasConcept C2776694085 @default.
• W2758176523 hasConcept C2777757722 @default.
• W2758176523 hasConcept C2779572924 @default.
• W2758176523 hasConcept C2779733811 @default.
• W2758176523 hasConcept C3019096185 @default.
• W2758176523 hasConcept C509974204 @default.
• W2758176523 hasConcept C530470458 @default.
• W2758176523 hasConcept C55493867 @default.
• W2758176523 hasConcept C71924100 @default.
• W2758176523 hasConceptScore W2758176523C104317684 @default.
• W2758176523 hasConceptScore W2758176523C121608353 @default.
• W2758176523 hasConceptScore W2758176523C126322002 @default.
• W2758176523 hasConceptScore W2758176523C142724271 @default.
• W2758176523 hasConceptScore W2758176523C143998085 @default.
• W2758176523 hasConceptScore W2758176523C150194340 @default.
• W2758176523 hasConceptScore W2758176523C185592680 @default.

• next