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- W2758334442 abstract "Radiation became a pillar of oncologic treatment in the last century and provided a powerful and effective locoregional treatment of solid malignancies. After achieving some of the first cures in lymphomas and skin cancers, it assumed a key role in the curative treatment of epithelioid malignancies. Despite success across a variety of histologic types, glioblastoma (GBM), the most common primary brain tumor afflicting adults, remains ultimately resistant to current radiation strategies. While GBMs demonstrate an initial response, recurrence is essentially universal and fatal and typically reoccur in the areas that received the most intense radiation. Glioma stem cells (GSCs), a subpopulation of tumor cells with expression profiles similar to neural stem cells and marked self-renewal capacities, have been shown to drive tumor recurrence and preclude curative radiotherapy. Recent research has shown that these cells have enhanced DNA repair capacity and elevated resistance to cytotoxic ion fluxes and escape multimodality therapies. We will analyze the current understanding of GSCs and radiation by highlighting key discoveries probing their ability to withstand radiotherapy. We then speculate on novel mechanisms by which GSC can be made sensitive to or specifically targeted by radiation therapy." @default.
- W2758334442 created "2017-10-06" @default.
- W2758334442 creator A5009246073 @default.
- W2758334442 creator A5024048256 @default.
- W2758334442 creator A5024518009 @default.
- W2758334442 date "2017-10-02" @default.
- W2758334442 modified "2023-10-10" @default.
- W2758334442 title "Radiotherapy and Glioma Stem Cells: Searching for Chinks in Cellular Armor" @default.
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- W2758334442 cites W1634946633 @default.
- W2758334442 cites W1805451181 @default.
- W2758334442 cites W1981705266 @default.
- W2758334442 cites W1986595219 @default.
- W2758334442 cites W1988213418 @default.
- W2758334442 cites W1988508361 @default.
- W2758334442 cites W1995596330 @default.
- W2758334442 cites W1996181662 @default.
- W2758334442 cites W2001544973 @default.
- W2758334442 cites W2010954323 @default.
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- W2758334442 cites W2019028325 @default.
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- W2758334442 cites W2024903578 @default.
- W2758334442 cites W2024999465 @default.
- W2758334442 cites W2025183726 @default.
- W2758334442 cites W2027630134 @default.
- W2758334442 cites W2029445057 @default.
- W2758334442 cites W2033961707 @default.
- W2758334442 cites W2042400800 @default.
- W2758334442 cites W2051166342 @default.
- W2758334442 cites W2051588629 @default.
- W2758334442 cites W2051754271 @default.
- W2758334442 cites W2057132693 @default.
- W2758334442 cites W2059589551 @default.
- W2758334442 cites W2060551076 @default.
- W2758334442 cites W2067478716 @default.
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- W2758334442 cites W2084969545 @default.
- W2758334442 cites W2088911689 @default.
- W2758334442 cites W2089403922 @default.
- W2758334442 cites W2090971379 @default.
- W2758334442 cites W2106675906 @default.
- W2758334442 cites W2108294913 @default.
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- W2758334442 cites W2117767331 @default.
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- W2758334442 cites W2128130529 @default.
- W2758334442 cites W2130447102 @default.
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- W2758334442 cites W2145200068 @default.
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- W2758334442 cites W2252688218 @default.
- W2758334442 cites W2291986476 @default.
- W2758334442 cites W2299337834 @default.
- W2758334442 cites W2303803372 @default.
- W2758334442 cites W2306179365 @default.
- W2758334442 cites W2313572017 @default.
- W2758334442 cites W2336787231 @default.
- W2758334442 cites W2341448642 @default.
- W2758334442 cites W2341704169 @default.
- W2758334442 cites W2343839232 @default.
- W2758334442 cites W2488777145 @default.
- W2758334442 cites W2515564255 @default.
- W2758334442 cites W2527734859 @default.
- W2758334442 cites W2561012755 @default.
- W2758334442 cites W2569221217 @default.
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- W2758334442 cites W2588094244 @default.
- W2758334442 cites W2594763527 @default.
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- W2758334442 doi "https://doi.org/10.1007/s40778-017-0102-8" @default.
- W2758334442 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5772980" @default.
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- W2758334442 hasPublicationYear "2017" @default.
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