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• W2758372289 abstract "Abstract ALF Pm 6, a member of antimicrobial peptide in the antilipopolysaccharide factor (ALF) family from Penaeus monodon , plays important roles in shrimp immunity against pathogens. However, its antimicrobial activity and underlying mechanism have not been reported. The synthetic cyclic ALF Pm 6#29–52 peptide (cALF Pm 6#29–52) corresponding to the ALF Pm 6 LPS-binding domain can agglutinate and exhibited bacterial killing activity toward a Gram-negative bacterium, Escherichia coli 363 and Gram-positive bacteria, Bacillus megaterium , Aerococcus viridans , and Micrococcus luteus , with MIC values of 25–50 μ M. Specifically, ALF Pm 6 and ALF Pm 3, the most abundant ALF isoforms, are different in terms of gene expression patterns upon pathogen infections. Herein, the regulation of ALF Pm 3 and ALF Pm 6 gene expression was studied. The 5′-upstream and promoter sequences were identified and the putative transcription factor (TF)-binding sites were predicted. The narrow down assay indicated that the ALF Pm 3 promoter and partial promoter of the ALF Pm 6 active regions were located at nucleotide positions (−814/+302) and (−282/+85), respectively. Mutagenesis of selected TF-binding sites revealed that Rel/NF- κ B (−280/−270) of ALF Pm 3 and C/EBP β (−88/−78) and Sp1 (−249/−238) sites of ALF Pm 6 were the activator-binding sites. Knockdown of the Pm MyD88 and Pm Relish genes in V . harveyi -infected shrimp suggested that the ALF Pm 3 gene was regulated by Toll and IMD pathways, while the ALF Pm 6 gene was regulated by the Toll pathway." @default.
• W2758372289 created "2017-10-06" @default.
• W2758372289 creator A5018682974 @default.
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• W2758372289 date "2017-10-04" @default.
• W2758372289 modified "2023-10-16" @default.
• W2758372289 title "Regulation of antilipopolysaccharide factors, ALFPm3 and ALFPm6, in Penaeus monodon" @default.
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• W2758372289 doi "https://doi.org/10.1038/s41598-017-12137-5" @default.
• W2758372289 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5627258" @default.
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