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- W275847006 abstract "It was found previously that exposure to ionizing radiation depresses the participation of the cell not only in the mitosis but also in the DNA synthesis, with a subsequent increase of the proliferation during the regeneration period. In order to further clarify this problem, a study was carried out on the possibility of synthetizing DNA in the cell components of the nervous system, examining the effect of ionizing radiation on this process. H/ sup 3/-thymidine, a specific precursor of DNA was used as the radioactive tracer material. Female white rats were exposed to 600 or 770 r of whole-body radiation at a rate of 49.8 r/minute. The tracer was injected subcutaneously at periods ranging from 1 to 240 hours after exposure, at a dose of 0.5 mu c/g body weight, killing the animals 4, 24, or 48 hours after the injection. Unirradiated animals served as controls. The brain and the spinal cord and other parts of the body were subjected to autoradiography, checking the tritiated nuclei and the mitosia. This was allowed to follow the movement of the neuroblasts to the skin where they continue to differentiate and lose their ability to undergo fission. However, autoradiography did not reveal anymore » synthesis of DNA. The injury phase was followed by a recovery phase. (TTT)« less" @default.
- W275847006 created "2016-06-24" @default.
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- W275847006 date "1963-01-01" @default.
- W275847006 modified "2023-09-23" @default.
- W275847006 title "AUTORADIOGRAPHIC INVESTIGATIONS WITH H$sup 3$-THYMIDINE FROM THE SYNTHESIS OF DESOXYRIBONUCLEIC ACID IN CELL COMPONENTS OF WHITE RATS AFTER WHOLE-BODY IRRADIATION BY X-RAYS" @default.
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