Matches in SemOpenAlex for { <https://semopenalex.org/work/W2758597910> ?p ?o ?g. }
Showing items 1 to 72 of
72
with 100 items per page.
- W2758597910 endingPage "248" @default.
- W2758597910 startingPage "248" @default.
- W2758597910 abstract "Objective: Vitamin D receptor (VDR) mediated Vitamin D signaling is important for expression of insulin gene and glucose transporters, which help in glucose uptake by cells. Current evidence suggests that four common polymorphisms (FokI, BsmI, ApaI, TaqI) of VDR gene are associated with Type 2 diabetes mellitus (T2DM) in different populations. However, there is a scarcity of data on VDR polymorphisms from Indian population.Methods: In the current study, total genomic DNA was isolated from 100 well-characterized T2DM patients and 100 healthy controls. We investigated the prevalence of FokI and ApaI polymorphisms in VDR gene of these patients by polymerase chain reaction-restriction fragment length polymorphism-based method. Taking help of our previous published data on TaqI and BsmI polymorphisms in same patients, the haplotype study was also conducted. Statistical analysis of data was performed using SPSS 21.0 software. Haplotype and linkage disequilibrium analysis was performed by Haploview software.Results: Both the wild (TT) and mutant (CC) genotype of FokI polymorphism showed a significant difference between patients and controls (p<0.001 and p<0.001, respectively). The frequency of mutant allele (C) was also significantly higher in T2DM patients than the controls (p<0.001). In case of ApaI, frequency of wild (GG) and mutant (CC) genotype was significantly different in patients and controls (p=0.017 and p=0.034). As per haplotype analysis, the CACT haplotype was predicted to be of significance in patients and consists of mutant alleles of three polymorphisms (FokI, BsmI, ApaI). Conclusion: Our study supports the association of FokI and ApaI polymorphism in T2DM. The haplotype analysis also indicates that the combinations of mutant allele of different VDR polymorphisms are probably responsible for increased susceptibility of these individuals toward T2DM." @default.
- W2758597910 created "2017-10-06" @default.
- W2758597910 creator A5045598473 @default.
- W2758597910 creator A5084231903 @default.
- W2758597910 creator A5088906706 @default.
- W2758597910 date "2017-09-01" @default.
- W2758597910 modified "2023-09-23" @default.
- W2758597910 title "VITAMIN D RECEPTOR GENE POLYMORPHISMS AND HAPLOTYPE ANALYSIS IN TYPE 2 DIABETES MELLITUS PATIENTS FROM NORTH INDIA" @default.
- W2758597910 doi "https://doi.org/10.22159/ajpcr.2017.v10i10.20453" @default.
- W2758597910 hasPublicationYear "2017" @default.
- W2758597910 type Work @default.
- W2758597910 sameAs 2758597910 @default.
- W2758597910 citedByCount "1" @default.
- W2758597910 countsByYear W27585979102021 @default.
- W2758597910 crossrefType "journal-article" @default.
- W2758597910 hasAuthorship W2758597910A5045598473 @default.
- W2758597910 hasAuthorship W2758597910A5084231903 @default.
- W2758597910 hasAuthorship W2758597910A5088906706 @default.
- W2758597910 hasBestOaLocation W27585979101 @default.
- W2758597910 hasConcept C104317684 @default.
- W2758597910 hasConcept C126322002 @default.
- W2758597910 hasConcept C134018914 @default.
- W2758597910 hasConcept C135763542 @default.
- W2758597910 hasConcept C149737253 @default.
- W2758597910 hasConcept C179639408 @default.
- W2758597910 hasConcept C180754005 @default.
- W2758597910 hasConcept C197754878 @default.
- W2758597910 hasConcept C2779105492 @default.
- W2758597910 hasConcept C2781308329 @default.
- W2758597910 hasConcept C2910068830 @default.
- W2758597910 hasConcept C35605836 @default.
- W2758597910 hasConcept C54355233 @default.
- W2758597910 hasConcept C555293320 @default.
- W2758597910 hasConcept C71924100 @default.
- W2758597910 hasConcept C86803240 @default.
- W2758597910 hasConceptScore W2758597910C104317684 @default.
- W2758597910 hasConceptScore W2758597910C126322002 @default.
- W2758597910 hasConceptScore W2758597910C134018914 @default.
- W2758597910 hasConceptScore W2758597910C135763542 @default.
- W2758597910 hasConceptScore W2758597910C149737253 @default.
- W2758597910 hasConceptScore W2758597910C179639408 @default.
- W2758597910 hasConceptScore W2758597910C180754005 @default.
- W2758597910 hasConceptScore W2758597910C197754878 @default.
- W2758597910 hasConceptScore W2758597910C2779105492 @default.
- W2758597910 hasConceptScore W2758597910C2781308329 @default.
- W2758597910 hasConceptScore W2758597910C2910068830 @default.
- W2758597910 hasConceptScore W2758597910C35605836 @default.
- W2758597910 hasConceptScore W2758597910C54355233 @default.
- W2758597910 hasConceptScore W2758597910C555293320 @default.
- W2758597910 hasConceptScore W2758597910C71924100 @default.
- W2758597910 hasConceptScore W2758597910C86803240 @default.
- W2758597910 hasIssue "10" @default.
- W2758597910 hasLocation W27585979101 @default.
- W2758597910 hasOpenAccess W2758597910 @default.
- W2758597910 hasPrimaryLocation W27585979101 @default.
- W2758597910 hasRelatedWork W130755238 @default.
- W2758597910 hasRelatedWork W1994861742 @default.
- W2758597910 hasRelatedWork W2110343942 @default.
- W2758597910 hasRelatedWork W2141582673 @default.
- W2758597910 hasRelatedWork W2287028800 @default.
- W2758597910 hasRelatedWork W2351757521 @default.
- W2758597910 hasRelatedWork W2393966429 @default.
- W2758597910 hasRelatedWork W2758597910 @default.
- W2758597910 hasRelatedWork W4285798645 @default.
- W2758597910 hasRelatedWork W4321445867 @default.
- W2758597910 hasVolume "10" @default.
- W2758597910 isParatext "false" @default.
- W2758597910 isRetracted "false" @default.
- W2758597910 magId "2758597910" @default.
- W2758597910 workType "article" @default.