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• W2758598052 abstract "Microsatellites instability (MSI) is a risk factor for multiple primary cancers (MPCs). However, a variety of studies focused on the risk in the hereditary non-polyposis colorectal cancer (HNPCC) not the sporadic colorectal cancer (CRC) patients. The aim of this meta-analysis was to comprehensive overview and quantitative summary the association between MSI and risk of MPCs. A comprehensive literature search in MEDLINE, EMBASE, Web of science, ScienceDirect, Weily and OVID was conducted. Up to May 2016, we identified 22 observational studies. We calculated the summary relative risk (RR) for the risk of MPCs in MSI patients compared with microsatellites stability (MSS) patients using fixed- or random-effects models. The RR of the association between mismatch-repair gene (MMR) genotype and MPCs was 2.59 (95% confidence interval [CI], 2.06 to 3.27); the RR was 2.14 (95% CI, 1.78 to 2.57) for sporadic CRC and 5.59 (95% CI, 2.69 to 11.59) for HNPCC for the MSI versus MSS category. The subgroup analyses showed different mutant gene, mutant locus, and mutant level of MMR with different influence on the patients susceptible to MPCs. In addition, MSI genotype increase the risk of MPC was not associated with an apparently specific in regard to site, timing, age and detection method. In conclusion, this meta-analysis indicates that MSI is associated with an increased risk of MPCs both in the HNPCC and sporadic CRC patients. Our findings will form the backbone of the treatment for MSI genotype may be an important valuable strategy for MPCs prevention." @default.
• W2758598052 created "2017-10-06" @default.
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• W2758598052 date "2017-01-01" @default.
• W2758598052 modified "2023-10-05" @default.
• W2758598052 title "Association between Mismatch-repair Genetic variation and the Risk of Multiple Primary Cancers: A Meta-Analysis" @default.
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• W2758598052 cites W1970415574 @default.
• W2758598052 cites W1972495126 @default.
• W2758598052 cites W1975836293 @default.
• W2758598052 cites W1977540350 @default.
• W2758598052 cites W1984642649 @default.
• W2758598052 cites W1994742596 @default.
• W2758598052 cites W1996328399 @default.
• W2758598052 cites W1998918529 @default.
• W2758598052 cites W2001471795 @default.
• W2758598052 cites W2006266845 @default.
• W2758598052 cites W2017727119 @default.
• W2758598052 cites W2024785360 @default.
• W2758598052 cites W2026017896 @default.
• W2758598052 cites W2036464787 @default.
• W2758598052 cites W2047041699 @default.
• W2758598052 cites W2047286769 @default.
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• W2758598052 cites W2054393991 @default.
• W2758598052 cites W2054480936 @default.
• W2758598052 cites W2055861615 @default.
• W2758598052 cites W2056817435 @default.
• W2758598052 cites W2057349193 @default.
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• W2758598052 cites W2074730941 @default.
• W2758598052 cites W2089855837 @default.
• W2758598052 cites W2089968043 @default.
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• W2758598052 cites W2116475791 @default.
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• W2758598052 doi "https://doi.org/10.7150/jca.19810" @default.
• W2758598052 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5665047" @default.
• W2758598052 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29158803" @default.
• W2758598052 hasPublicationYear "2017" @default.
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