Matches in SemOpenAlex for { <https://semopenalex.org/work/W2758611845> ?p ?o ?g. }
Showing items 1 to 75 of
75
with 100 items per page.
- W2758611845 abstract "Background: Stem cell therapy has recently shown promise in the prevention of diabetic complications due to its regenerative potential. The possible applications of human diabetic adipose tissue-derived mesenchymal stem cells (dAT-MSCs) in cell therapy are limited because their characteristics are still not fully understood. Aims: This study aimed to characterize dAT-MSCs in vitro and to investigate the potential application of dAT-MSCs in wound healing. Materials and Methods: dAT-MSCs were characterized under normoxic and hypoxic conditions in vitro and evaluated wound healing capacity in the ischemic flap mouse model. Results: Early growth response factor-1 (EGR-1) and its target genes were highly expressed in dAT-MSCs in comparison to nAT-MSCs, resulting in increasing of genes and protein associated with cell adhesion, insulin resistance, and impaired wound healing. Interestingly, under hypoxic conditions, hypoxia-inducible factor-1α (HIF-1α) can bind to the EGR-1 promoter in dAT-MSCs, but not in nAT-MSCs. The effects of EGR-1 were inhibited by shEGR-1 and PD98059. Mice injected with shEGR-1- dAT-MSCs were improved their wound healing capacity. Furthermore, we found that human nAT-MSC-derived microvesicles (nMVs) could improve dAT-MSC function by altering miRNA and mRNA expressions, which enhanced their migration ability in vitro and wound healing capacity in the ischemic flap mouse model. Conclusion: Our study suggests that dAT-MSCs may contribute to delay wound healing. Interrupting the expression of EGR-1 in dAT-MSCs or transfecting nMVs to dAT-MSCs may be a useful treatment for chronic wounds in diabetic patients." @default.
- W2758611845 created "2017-10-06" @default.
- W2758611845 creator A5018890850 @default.
- W2758611845 date "2017-09-05" @default.
- W2758611845 modified "2023-10-17" @default.
- W2758611845 title "ID2019 Functional analysis of human type 2 diabetic adipose tissue-derived mesenchymal stem cells" @default.
- W2758611845 doi "https://doi.org/10.15419/bmrat.v4is.262" @default.
- W2758611845 hasPublicationYear "2017" @default.
- W2758611845 type Work @default.
- W2758611845 sameAs 2758611845 @default.
- W2758611845 citedByCount "0" @default.
- W2758611845 crossrefType "journal-article" @default.
- W2758611845 hasAuthorship W2758611845A5018890850 @default.
- W2758611845 hasBestOaLocation W27586118451 @default.
- W2758611845 hasConcept C104317684 @default.
- W2758611845 hasConcept C10882517 @default.
- W2758611845 hasConcept C126322002 @default.
- W2758611845 hasConcept C145059251 @default.
- W2758611845 hasConcept C171089720 @default.
- W2758611845 hasConcept C198826908 @default.
- W2758611845 hasConcept C203014093 @default.
- W2758611845 hasConcept C20518536 @default.
- W2758611845 hasConcept C2779389132 @default.
- W2758611845 hasConcept C2780269544 @default.
- W2758611845 hasConcept C2781051411 @default.
- W2758611845 hasConcept C28328180 @default.
- W2758611845 hasConcept C502942594 @default.
- W2758611845 hasConcept C55493867 @default.
- W2758611845 hasConcept C71924100 @default.
- W2758611845 hasConcept C86803240 @default.
- W2758611845 hasConcept C95444343 @default.
- W2758611845 hasConceptScore W2758611845C104317684 @default.
- W2758611845 hasConceptScore W2758611845C10882517 @default.
- W2758611845 hasConceptScore W2758611845C126322002 @default.
- W2758611845 hasConceptScore W2758611845C145059251 @default.
- W2758611845 hasConceptScore W2758611845C171089720 @default.
- W2758611845 hasConceptScore W2758611845C198826908 @default.
- W2758611845 hasConceptScore W2758611845C203014093 @default.
- W2758611845 hasConceptScore W2758611845C20518536 @default.
- W2758611845 hasConceptScore W2758611845C2779389132 @default.
- W2758611845 hasConceptScore W2758611845C2780269544 @default.
- W2758611845 hasConceptScore W2758611845C2781051411 @default.
- W2758611845 hasConceptScore W2758611845C28328180 @default.
- W2758611845 hasConceptScore W2758611845C502942594 @default.
- W2758611845 hasConceptScore W2758611845C55493867 @default.
- W2758611845 hasConceptScore W2758611845C71924100 @default.
- W2758611845 hasConceptScore W2758611845C86803240 @default.
- W2758611845 hasConceptScore W2758611845C95444343 @default.
- W2758611845 hasLocation W27586118451 @default.
- W2758611845 hasOpenAccess W2758611845 @default.
- W2758611845 hasPrimaryLocation W27586118451 @default.
- W2758611845 hasRelatedWork W2023153920 @default.
- W2758611845 hasRelatedWork W2031181581 @default.
- W2758611845 hasRelatedWork W2041386692 @default.
- W2758611845 hasRelatedWork W2050536754 @default.
- W2758611845 hasRelatedWork W2078961618 @default.
- W2758611845 hasRelatedWork W2148242495 @default.
- W2758611845 hasRelatedWork W2171530841 @default.
- W2758611845 hasRelatedWork W2279896068 @default.
- W2758611845 hasRelatedWork W2575044982 @default.
- W2758611845 hasRelatedWork W2735886478 @default.
- W2758611845 hasRelatedWork W2769081885 @default.
- W2758611845 hasRelatedWork W2885510394 @default.
- W2758611845 hasRelatedWork W2982850981 @default.
- W2758611845 hasRelatedWork W2991149340 @default.
- W2758611845 hasRelatedWork W2992227344 @default.
- W2758611845 hasRelatedWork W3038122116 @default.
- W2758611845 hasRelatedWork W3087054820 @default.
- W2758611845 hasRelatedWork W3161201485 @default.
- W2758611845 hasRelatedWork W3194413652 @default.
- W2758611845 hasRelatedWork W3198236288 @default.
- W2758611845 isParatext "false" @default.
- W2758611845 isRetracted "false" @default.
- W2758611845 magId "2758611845" @default.
- W2758611845 workType "article" @default.