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- W2758698982 abstract "Prostate cancer(PCa) is one of the most common cancers in the world, and the population of patients with intermediate- to high-risk localized prostate cancer occupies a large proportion. The results of treatment after hypofractionated radiotherapy only have been reported from several small randomized trials. Therefore, we pooled the relevant data and conducted a meta-analysis to compare clinical outcomes of hypofractionated radiotherapy versus conventional radiotherapy in the treatment of intermediate- to high-risk localized PCa. Relevant studies were identified through searching PubMed, Embase and Web of Science databases till August, 2016. Hazard ratio (HR) or risk ratio (RR) with its corresponding 95% confidence interval (CI) was used as pooled statistics for all analyses. Five clinical cohorts were included with a total of 1621 intermediate- to high-risk localized PCa patients. The meta-analysis results showed that overall survival (HR=1.00, 95% CI: 0.85-1.17, p=0.980) and biochemical failure (RR=0.87, 95% CI: 0.68-1.12, p=0.274) were similar in two groups. The incidence of acute adverse gastrointestinal event (grade ≥ 2) was higher in the hypofractionated radiotherapy (RR=1.94, 95% CI: 1.23-3.06, p=0.004). Acute genitourinary adverse event (grade ≥ 2) was similar among the groups (RR=1.03, 95% CI: 0.92-1.14, p=0.626). Gastrointestinal (RR=1.17, 95% CI: 0.90-1.51, p=0.238) or genitourinary (RR=1.11, 95% CI: 0.94-1.30, p=0.228) late adverse event (grade ≥ 2) data were not significant differences between two radiotherapy schedules. No publication bias was detected in this meta-analysis (all p>0.05). Compared with conventional radiotherapy, hypofractionated radiotherapy has achieved similar clinical outcomes in patients with intermediate- to high-risk localized PCa. Although hypofractionated radiotherapy has an increased incidence rate of in acute gastrointestinal adverse events, the late gastrointestinal and genitourinary adverse events were similar in two groups, and the patients could be tolerable." @default.
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- W2758698982 date "2017-10-01" @default.
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- W2758698982 title "Hypofractionated Radiation Therapy Versus Conventional Radiation Therapy in Patients With Intermediate- to High-Risk Localized Prostate Cancer" @default.
- W2758698982 doi "https://doi.org/10.1016/j.ijrobp.2017.06.1169" @default.
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