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- W2758699621 abstract "Neuroinflammation involves cytokine release, astrocyte reactivity and migration. Neuronal Thy-1 promotes DITNC1 astrocyte migration by engaging αVβ3 Integrin and Syndecan-4. Primary astrocytes express low levels of these receptors and are unresponsive to Thy-1; thus, inflammation and astrocyte reactivity might be necessary for Thy-1-induced responses. Wild-type rat astrocytes (TNF-activated) or from human SOD1G93A transgenic mice (a neurodegenerative disease model) were used to evaluate cell migration, Thy-1 receptor levels, signaling molecules, and reactivity markers. Thy-1 induced astrocyte migration only after TNF priming. Increased expression of αVβ3 Integrin, Syndecan-4, P2X7R, Pannexin-1, Connexin-43, GFAP, and iNOS were observed in TNF-treated astrocytes. Silencing of β3 Integrin prior to TNF treatment prevented Thy-1-induced migration, while β3 Integrin over-expression was sufficient to induce astrocyte reactivity and allow Thy-1-induced migration. Finally, hSOD1G93A astrocytes behave as TNF-treated astrocytes since they were reactive and responsive to Thy-1. Therefore, inflammation induces expression of αVβ3 Integrin and other proteins, astrocyte reactivity, and Thy-1 responsiveness. Importantly, ectopic control of β3 Integrin levels modulates these responses regardless of inflammation." @default.
- W2758699621 created "2017-10-06" @default.
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- W2758699621 date "2017-09-29" @default.
- W2758699621 modified "2023-10-16" @default.
- W2758699621 title "αVβ3 Integrin regulates astrocyte reactivity" @default.
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- W2758699621 doi "https://doi.org/10.1186/s12974-017-0968-5" @default.
- W2758699621 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5622429" @default.
- W2758699621 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28962574" @default.
- W2758699621 hasPublicationYear "2017" @default.
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