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• W2758707058 abstract "Somatostatin (SST) receptors belong to the seven-transmembrane domain G-protein-coupled receptors superfamily and exist in five different subtypes. They are widely distributed in many tissues in the human body where they mediate several physiological actions of the native SST hormone. In addition, they are also overexpressed in many tumor cells especially in pituitary adenomas and neuroendocrine neoplasms of the gastrointestinal system. This fact has constituted the basis for development of highly specific and sensitive imaging modalities for in vivo visualization and selective irradiation of such tumors using radiolabeled SST analogues. However, heterogeneous distribution of the five known SST receptor subtypes between different tumor types, and even within the same tumor, can be challenging in the diagnostic approach and can produce considerable variability in responsiveness to therapies targeting these receptors. Therefore, detection of SST receptors and subtype profiling using in vivo and in vitro methods is increasingly gaining clinical attention." @default.
• W2758707058 created "2017-10-06" @default.
• W2758707058 creator A5037557664 @default.
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• W2758707058 date "2019-01-01" @default.
• W2758707058 modified "2023-09-24" @default.
• W2758707058 title "Somatostatin Receptor Expression in Gastrointestinal Tumors" @default.
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• W2758707058 doi "https://doi.org/10.1016/b978-0-12-801238-3.64282-4" @default.
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