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- W2758723310 abstract "The Niemann Pick disease type C1 (NPC1) is a lysosomal storage disorder caused by a mutation in the NPC1 gene. The mutation disrupts the normal cholesterol traficking and induces cholesterol accumulation in cells of the liver and the brain. Till now, no therapy exists for NPC1 patients. But recently, pneumococci immunization has shown to reduce inflammation in Non-alcoholic steatohepatitis (NASH), another lipid storage disorder. Therefore, pneumococci immunization was also tested on NPC1mut mice. The results indicate an improved pathology in the NPC1 mice after the immunization" @default.
- W2758723310 created "2017-10-06" @default.
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- W2758723310 date "2017-01-06" @default.
- W2758723310 modified "2023-09-24" @default.
- W2758723310 title "Protective mechanism in NPC1 – the role of oxLDL" @default.
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- W2758723310 doi "https://doi.org/10.26481/marble.2015.v6.373" @default.
- W2758723310 hasPublicationYear "2017" @default.
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