Matches in SemOpenAlex for { <https://semopenalex.org/work/W2758725298> ?p ?o ?g. }
Showing items 1 to 83 of
83
with 100 items per page.
- W2758725298 abstract "<p><strong>Objective</strong>: A decrease in granular convoluted tubule (GCT) cells and acini occurs in the submandibular glands of castrated female rats, while in rats submitted to hormone replacement and phytotherapy with soy isoflavones, this effect is reversed. This study aimed to elucidate the mechanisms through which these changes occur. <strong>Material and Methods</strong>: Rats (n=84) were ovariectomized and 21 were sham-operated. Ovariectomized rats were randomly subdivided and orally administered the following: 17 β-estradiol (OVX-E; n=21), 15 mg/kg/day of soy isoflavone extract (OVX-I; n=21), 17 β-estradiol + soy isoflavone extract (OVX-A; n=21); and water as placebo (OVX; n=21). The rats were euthanized three, five and eight weeks after ovariectomy. The submandibular salivary glands were submitted to histological processing with HE stain and immunohistochemistry was performed using the streptavidin-biotin-peroxidase complex. The cell area and the expression of proliferating cell nuclear antigen and estrogen receptor β were evaluated. <strong>Results</strong>: The results were statistically analyzed by ANOVA and Tukey test. A decrease in the area of GCT cells in the OVX, was observed, in contrast with an increase in the OVX-E. PCNA in the acinar cells and estrogen receptors were elevated in the OVX-I group. <strong>Conclusion</strong>: Castration exerts an immediate reductive effect on the volume of GCT cells. Estrogens, soy isoflavones and their combination have different mechanisms of action on the homeostasis of the gland. Estrogens cause an increase in GCT cells area, while isoflavones enhance cell proliferation and the expression of estrogen receptor-β. Their association showed no additional increase in the effect studied.</p><p><strong>Keywords</strong></p><p>Estrogen; Morphometry; Salivary glands; Soy isoflavones.</p>" @default.
- W2758725298 created "2017-10-06" @default.
- W2758725298 creator A5009515558 @default.
- W2758725298 creator A5014498746 @default.
- W2758725298 creator A5034852103 @default.
- W2758725298 creator A5056055921 @default.
- W2758725298 creator A5062555257 @default.
- W2758725298 creator A5064504548 @default.
- W2758725298 date "2017-09-26" @default.
- W2758725298 modified "2023-10-04" @default.
- W2758725298 title "Effects of ovariectomy, estrogen and soy isoflavones in rats submandibular glands" @default.
- W2758725298 doi "https://doi.org/10.14295/bds.2017.v20i3.1443" @default.
- W2758725298 hasPublicationYear "2017" @default.
- W2758725298 type Work @default.
- W2758725298 sameAs 2758725298 @default.
- W2758725298 citedByCount "0" @default.
- W2758725298 crossrefType "journal-article" @default.
- W2758725298 hasAuthorship W2758725298A5009515558 @default.
- W2758725298 hasAuthorship W2758725298A5014498746 @default.
- W2758725298 hasAuthorship W2758725298A5034852103 @default.
- W2758725298 hasAuthorship W2758725298A5056055921 @default.
- W2758725298 hasAuthorship W2758725298A5062555257 @default.
- W2758725298 hasAuthorship W2758725298A5064504548 @default.
- W2758725298 hasBestOaLocation W27587252981 @default.
- W2758725298 hasConcept C121608353 @default.
- W2758725298 hasConcept C126322002 @default.
- W2758725298 hasConcept C134018914 @default.
- W2758725298 hasConcept C185592680 @default.
- W2758725298 hasConcept C204232928 @default.
- W2758725298 hasConcept C2777014122 @default.
- W2758725298 hasConcept C2777164284 @default.
- W2758725298 hasConcept C2778270713 @default.
- W2758725298 hasConcept C2779705811 @default.
- W2758725298 hasConcept C2780266248 @default.
- W2758725298 hasConcept C34688535 @default.
- W2758725298 hasConcept C530470458 @default.
- W2758725298 hasConcept C55493867 @default.
- W2758725298 hasConcept C71924100 @default.
- W2758725298 hasConcept C8264082 @default.
- W2758725298 hasConcept C84606932 @default.
- W2758725298 hasConceptScore W2758725298C121608353 @default.
- W2758725298 hasConceptScore W2758725298C126322002 @default.
- W2758725298 hasConceptScore W2758725298C134018914 @default.
- W2758725298 hasConceptScore W2758725298C185592680 @default.
- W2758725298 hasConceptScore W2758725298C204232928 @default.
- W2758725298 hasConceptScore W2758725298C2777014122 @default.
- W2758725298 hasConceptScore W2758725298C2777164284 @default.
- W2758725298 hasConceptScore W2758725298C2778270713 @default.
- W2758725298 hasConceptScore W2758725298C2779705811 @default.
- W2758725298 hasConceptScore W2758725298C2780266248 @default.
- W2758725298 hasConceptScore W2758725298C34688535 @default.
- W2758725298 hasConceptScore W2758725298C530470458 @default.
- W2758725298 hasConceptScore W2758725298C55493867 @default.
- W2758725298 hasConceptScore W2758725298C71924100 @default.
- W2758725298 hasConceptScore W2758725298C8264082 @default.
- W2758725298 hasConceptScore W2758725298C84606932 @default.
- W2758725298 hasLocation W27587252981 @default.
- W2758725298 hasOpenAccess W2758725298 @default.
- W2758725298 hasPrimaryLocation W27587252981 @default.
- W2758725298 hasRelatedWork W1968528879 @default.
- W2758725298 hasRelatedWork W2018329936 @default.
- W2758725298 hasRelatedWork W2045025272 @default.
- W2758725298 hasRelatedWork W2080428673 @default.
- W2758725298 hasRelatedWork W2080565161 @default.
- W2758725298 hasRelatedWork W2112427515 @default.
- W2758725298 hasRelatedWork W2157415915 @default.
- W2758725298 hasRelatedWork W2178524850 @default.
- W2758725298 hasRelatedWork W2239900175 @default.
- W2758725298 hasRelatedWork W2249157007 @default.
- W2758725298 hasRelatedWork W2325911959 @default.
- W2758725298 hasRelatedWork W2335468551 @default.
- W2758725298 hasRelatedWork W2348926414 @default.
- W2758725298 hasRelatedWork W2350979938 @default.
- W2758725298 hasRelatedWork W2354373841 @default.
- W2758725298 hasRelatedWork W2357416475 @default.
- W2758725298 hasRelatedWork W2363060699 @default.
- W2758725298 hasRelatedWork W2368832531 @default.
- W2758725298 hasRelatedWork W2385939641 @default.
- W2758725298 hasRelatedWork W2444268026 @default.
- W2758725298 isParatext "false" @default.
- W2758725298 isRetracted "false" @default.
- W2758725298 magId "2758725298" @default.
- W2758725298 workType "article" @default.