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• W2758751954 abstract "Pituitary adenylate cyclase-activating polypeptide (PACAP) was first identified in hypothalamus, based on its ability to elevate cyclic AMP in the anterior pituitary. PACAP has been identified as the adrenomedullary neurotransmitter in stress through a combination of ex vivo, in vivo, and in cellula experiments over the past two decades. PACAP causes catecholamine secretion, and activation of catecholamine biosynthetic enzymes, during episodes of stress in mammals. Features of PACAP signaling allowing stress transduction at the splanchnicoadrenomedullary synapse have yielded insights into the contrasting roles of acetylcholine's and PACAP's actions as first messengers at the chromaffin cell, via differential release at low and high rates of splanchnic nerve firing, and differential signaling pathway engagement leading to catecholamine secretion and chromaffin cell gene transcription. Secretion stimulated by PACAP, via calcium influx independent of action potential generation, is under active investigation in several laboratories both at the chromaffin cell and within autonomic ganglia of both the parasympathetic and sympathetic nervous systems. PACAP is a neurotransmitter important in stress transduction in the central nervous system as well, and is found at stress-transduction nuclei in brain including the paraventricular nucleus of hypothalamus, the amygdala and extended amygdalar nuclei, and the prefrontal cortex. The current status of PACAP as a master regulator of stress signaling in the nervous system derives fundamentally from the establishment of its role as the splanchnicoadrenomedullary transmitter in stress. Experimental elucidation of PACAP action at this synapse remains at the forefront of understanding PACAP's role in stress signaling throughout the nervous system." @default.
• W2758751954 created "2017-10-06" @default.
• W2758751954 creator A5005746555 @default.
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• W2758751954 date "2017-09-30" @default.
• W2758751954 modified "2023-10-17" @default.
• W2758751954 title "PACAP signaling in stress: insights from the chromaffin cell" @default.
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• W2758751954 cites W1483345618 @default.
• W2758751954 cites W1492821183 @default.
• W2758751954 cites W1541362978 @default.
• W2758751954 cites W154704673 @default.
• W2758751954 cites W1584902624 @default.
• W2758751954 cites W1633358180 @default.
• W2758751954 cites W1777215729 @default.
• W2758751954 cites W1864730984 @default.
• W2758751954 cites W1919362256 @default.
• W2758751954 cites W1961069803 @default.
• W2758751954 cites W1963593519 @default.
• W2758751954 cites W1969618777 @default.
• W2758751954 cites W1980092530 @default.
• W2758751954 cites W1981423842 @default.
• W2758751954 cites W1981968644 @default.
• W2758751954 cites W1982474924 @default.
• W2758751954 cites W1990121017 @default.
• W2758751954 cites W1990361965 @default.
• W2758751954 cites W1996091038 @default.
• W2758751954 cites W1997499133 @default.
• W2758751954 cites W1998329385 @default.
• W2758751954 cites W2000626957 @default.
• W2758751954 cites W2004604151 @default.
• W2758751954 cites W2017971979 @default.
• W2758751954 cites W2019174692 @default.
• W2758751954 cites W2019655661 @default.
• W2758751954 cites W2020177718 @default.
• W2758751954 cites W2024118549 @default.
• W2758751954 cites W2024350982 @default.
• W2758751954 cites W2024958741 @default.
• W2758751954 cites W2031389208 @default.
• W2758751954 cites W2034346264 @default.
• W2758751954 cites W2036053907 @default.
• W2758751954 cites W2048335500 @default.
• W2758751954 cites W2048347960 @default.
• W2758751954 cites W2049059486 @default.
• W2758751954 cites W2049632104 @default.
• W2758751954 cites W2051653887 @default.
• W2758751954 cites W2056583482 @default.
• W2758751954 cites W2056882537 @default.
• W2758751954 cites W2058112769 @default.
• W2758751954 cites W2059268054 @default.
• W2758751954 cites W2060346226 @default.
• W2758751954 cites W2068344640 @default.
• W2758751954 cites W2068742213 @default.
• W2758751954 cites W2069195803 @default.
• W2758751954 cites W2069260204 @default.
• W2758751954 cites W2073634774 @default.
• W2758751954 cites W2073706728 @default.
• W2758751954 cites W2078032168 @default.
• W2758751954 cites W2086466427 @default.
• W2758751954 cites W2092250782 @default.
• W2758751954 cites W2096344641 @default.
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• W2758751954 cites W2107065417 @default.
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• W2758751954 cites W2117154038 @default.
• W2758751954 cites W2126940622 @default.
• W2758751954 cites W2130105549 @default.
• W2758751954 cites W2137229430 @default.
• W2758751954 cites W2137760362 @default.
• W2758751954 cites W2138001189 @default.
• W2758751954 cites W2141219931 @default.
• W2758751954 cites W2144400722 @default.
• W2758751954 cites W2148337375 @default.
• W2758751954 cites W2161538035 @default.
• W2758751954 cites W2161647215 @default.
• W2758751954 cites W2162360018 @default.
• W2758751954 cites W2164354034 @default.
• W2758751954 cites W2171483278 @default.
• W2758751954 cites W2172095199 @default.
• W2758751954 cites W2266355581 @default.
• W2758751954 cites W2404494800 @default.
• W2758751954 cites W2528927603 @default.
• W2758751954 cites W2565459181 @default.
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• W2758751954 doi "https://doi.org/10.1007/s00424-017-2062-3" @default.
• W2758751954 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5750103" @default.
• W2758751954 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28965274" @default.
• W2758751954 hasPublicationYear "2017" @default.
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