FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2758793032> ?p ?o ?g. }

• W2758793032 endingPage "53" @default.
• W2758793032 startingPage "46" @default.
• W2758793032 abstract "The peptides containing β- and γ-amino acids, LA-Lys-PEA, P1; LA-Lys-β3,3-Ac6c-PEA, P2; LA-Orn-β3,3-Ac6c-PEA, P3; LA-Lys-Gpn-PEA, P4; LA-Orn-Gpn-PEA, P5; LA-Lys-γ4-Phe-PEA, P6, LA-γ4-Leu-Lys-PEA, P7 and LA-β3,3-Pip(Ac)-Lys-PEA, P8 were synthesized, characterized and evaluated against Gram-positive and Gram-negative bacteria. Among all, peptides P2, P3, P4 and P5 exhibited potent activity (MIC 6.25μM) against S. aureus MTCC 737 and P. aeruginosa MTCC 424. In order to understand the efficacy of peptides and mechanism of action, time kill kinetics and fluorescence microscopic studies were performed against S. aureus and P. aeruginosa for the peptides P2, P3, P4 and P5. P4 took half time to show the bactericidal effect on P. aeruginosa and S. aureus in comparison to P2 at their 2x MICs. Fluorescence microscopic studies suggested that peptides P2 and P4 both killed the bacteria via membrane disruption. Further, P4 exhibited lowest haemolytic activity among active peptides and negligible cytotoxic activity against human cancer cell lines A-549, PC-3 and HCT-116 at its MIC." @default.
• W2758793032 created "2017-10-06" @default.
• W2758793032 creator A5006635775 @default.
• W2758793032 creator A5055757184 @default.
• W2758793032 creator A5056128213 @default.
• W2758793032 creator A5063924172 @default.
• W2758793032 creator A5069645446 @default.
• W2758793032 creator A5091556991 @default.
• W2758793032 date "2017-11-01" @default.
• W2758793032 modified "2023-10-14" @default.
• W2758793032 title "Short hybrid peptides incorporating β- and γ-amino acids as antimicrobial agents" @default.
• W2758793032 cites W1501359805 @default.
• W2758793032 cites W1560177375 @default.
• W2758793032 cites W1968670968 @default.
• W2758793032 cites W1975313075 @default.
• W2758793032 cites W1988230764 @default.
• W2758793032 cites W1993323777 @default.
• W2758793032 cites W1993703351 @default.
• W2758793032 cites W1997152791 @default.
• W2758793032 cites W2015271074 @default.
• W2758793032 cites W2030106420 @default.
• W2758793032 cites W2042790122 @default.
• W2758793032 cites W2044343085 @default.
• W2758793032 cites W2044991087 @default.
• W2758793032 cites W2050486326 @default.
• W2758793032 cites W2054602599 @default.
• W2758793032 cites W2058005783 @default.
• W2758793032 cites W2060306551 @default.
• W2758793032 cites W2068434462 @default.
• W2758793032 cites W2087043215 @default.
• W2758793032 cites W2092398381 @default.
• W2758793032 cites W2121597792 @default.
• W2758793032 cites W2130974803 @default.
• W2758793032 cites W2131508478 @default.
• W2758793032 cites W2144219110 @default.
• W2758793032 cites W2165482241 @default.
• W2758793032 cites W2229987747 @default.
• W2758793032 cites W2313701581 @default.
• W2758793032 cites W2313773476 @default.
• W2758793032 cites W2332717345 @default.
• W2758793032 cites W2601789957 @default.
• W2758793032 cites W2951476489 @default.
• W2758793032 cites W4211175230 @default.
• W2758793032 doi "https://doi.org/10.1016/j.peptides.2017.09.016" @default.
• W2758793032 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28962891" @default.
• W2758793032 hasPublicationYear "2017" @default.
• W2758793032 type Work @default.
• W2758793032 sameAs 2758793032 @default.
• W2758793032 citedByCount "20" @default.
• W2758793032 countsByYear W27587930322017 @default.
• W2758793032 countsByYear W27587930322018 @default.
• W2758793032 countsByYear W27587930322019 @default.
• W2758793032 countsByYear W27587930322020 @default.
• W2758793032 countsByYear W27587930322021 @default.
• W2758793032 countsByYear W27587930322022 @default.
• W2758793032 countsByYear W27587930322023 @default.
• W2758793032 crossrefType "journal-article" @default.
• W2758793032 hasAuthorship W2758793032A5006635775 @default.
• W2758793032 hasAuthorship W2758793032A5055757184 @default.
• W2758793032 hasAuthorship W2758793032A5056128213 @default.
• W2758793032 hasAuthorship W2758793032A5063924172 @default.
• W2758793032 hasAuthorship W2758793032A5069645446 @default.
• W2758793032 hasAuthorship W2758793032A5091556991 @default.
• W2758793032 hasConcept C176947019 @default.
• W2758793032 hasConcept C185592680 @default.
• W2758793032 hasConcept C202751555 @default.
• W2758793032 hasConcept C2776120743 @default.
• W2758793032 hasConcept C2779281246 @default.
• W2758793032 hasConcept C4937899 @default.
• W2758793032 hasConcept C515207424 @default.
• W2758793032 hasConcept C523546767 @default.
• W2758793032 hasConcept C540938839 @default.
• W2758793032 hasConcept C54355233 @default.
• W2758793032 hasConcept C55493867 @default.
• W2758793032 hasConcept C86803240 @default.
• W2758793032 hasConcept C89423630 @default.
• W2758793032 hasConceptScore W2758793032C176947019 @default.
• W2758793032 hasConceptScore W2758793032C185592680 @default.
• W2758793032 hasConceptScore W2758793032C202751555 @default.
• W2758793032 hasConceptScore W2758793032C2776120743 @default.
• W2758793032 hasConceptScore W2758793032C2779281246 @default.
• W2758793032 hasConceptScore W2758793032C4937899 @default.
• W2758793032 hasConceptScore W2758793032C515207424 @default.
• W2758793032 hasConceptScore W2758793032C523546767 @default.
• W2758793032 hasConceptScore W2758793032C540938839 @default.
• W2758793032 hasConceptScore W2758793032C54355233 @default.
• W2758793032 hasConceptScore W2758793032C55493867 @default.
• W2758793032 hasConceptScore W2758793032C86803240 @default.
• W2758793032 hasConceptScore W2758793032C89423630 @default.
• W2758793032 hasLocation W27587930321 @default.
• W2758793032 hasLocation W27587930322 @default.
• W2758793032 hasOpenAccess W2758793032 @default.
• W2758793032 hasPrimaryLocation W27587930321 @default.
• W2758793032 hasRelatedWork W2025373000 @default.
• W2758793032 hasRelatedWork W2093861618 @default.
• W2758793032 hasRelatedWork W2169720555 @default.
• W2758793032 hasRelatedWork W2536492202 @default.
• W2758793032 hasRelatedWork W2907154550 @default.

• next