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- W2758834944 abstract "ObjectiveTo predict the target genes and function of has-miR-26b, has-miR-1972, has-miR-4485, has-miR-4498, and has-miR-4743 by bioinformatics analysis, and provide the theoretical basis for the further research.MethodsThe targets of the five microRNAs were predicted by Target Scan, miRBD, and DIANA-microT-CDS, and the result were analyzed by gene ontology and pathway analysis using FunNet.Results734 predicted targets were obtained by finding the intersected genes of Target Scan, miRBD, and DIANA-microT-CDS.GO analysis showed that biological processes regulated by the differentially expressed microRNAs included diverse terms, among which some terms (e.g., central nervous system development, neuron differentiation, axonogenesis, synaptic transmission, learning, and memory, etc.) had direct relationship with the central nervous system and brain functions.The pathway analysis showed that a significant enrichment in several pathways related to neuronal brain function, such as axon guidance, glutamatergic synapse, Wnt signaling pathway, mTOR signaling pathway, VEGF signaling pathway, etc.Among the five microRNAs, has-miR-26b, has-miR-1972, has-miR-4498 might have more important regulatory functions.ConclusionBioinformatic analysis indicates that has-miR-26b, has-miR-1972, has-miR-4485, has-miR-4498, and has-miR-4743 are closely related to the mechanism and pathogenesis of major depressive disorder.Key words: MiRNA; Major depressive disorder; Target gene; Bioinformatics" @default.
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- W2758834944 date "2015-05-20" @default.
- W2758834944 modified "2023-09-25" @default.
- W2758834944 title "Bioinformatics analysis of microRNAs differently expressed in major depression disorder" @default.
- W2758834944 doi "https://doi.org/10.3760/cma.j.issn.1674-6554.2015.05.009" @default.
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