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- W2758902742 abstract "Modern medicine has been supported for many years by medical devices, which are frequently the only available solution for impaired organ function or structure. Medical devices have to be composed by biomaterials that comply with mechanical and physiological requirements specific for the relevant tissue/organ, without wrongly stimulating the host immune system. Albeit the undeniable importance of medical devices, they may also promote unwanted side effects, namely by enabling microbial colonization, promoting biofilm formation and establishment of chronic infection, resulting in application failure, and resuming or even exacerbating the initial/underlying problematic condition. Current antimicrobial treatments and prophylaxis of medical device-associated infection are based on systemic and/or local administration of conventional antibiotics and medical device removal in the case of confirmed persistent infection [1]. However, bacterial resistance development to current antibiotics has been reported a few years after their introduction into the clinics [2]. The decline in the effectiveness of current therapies has led to a search for new kinds of agents, including antimicrobial peptides (AMPs). Current chapter reviews AMP application on coating development, addressing the most important parameters that influence the antimicrobial activity of immobilized AMP." @default.
- W2758902742 created "2017-10-06" @default.
- W2758902742 creator A5006690381 @default.
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- W2758902742 creator A5041673356 @default.
- W2758902742 date "2018-01-01" @default.
- W2758902742 modified "2023-10-18" @default.
- W2758902742 title "Antimicrobial peptides (AMP) biomaterial coatings for tissue repair" @default.
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- W2758902742 doi "https://doi.org/10.1016/b978-0-08-100803-4.00013-9" @default.
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