FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2758904077> ?p ?o ?g. }

• W2758904077 endingPage "E291" @default.
• W2758904077 startingPage "E291" @default.
• W2758904077 abstract "Brachytherapy (BT) is an integral component in the multimodality management of carcinoma cervix; however studies (both in developed as well as developing countries) have shown its sub-optimal use, consequently affecting survival. Elderly patients of carcinoma cervix (E-CC) are a challenging group of patients to treat. We aimed to analyse the impact of BT usage on clinical outcome of E-CC patients treated with definitive radiotherapy (RT) with or without chemotherapy (CT) at our institute. 100 patients of E-CC (≥ 60 years) registered between Jan 2009 and Dec 2015 was included in this retrospective analysis. Medical charts were reviewed for: patient demographics, stage (FIGO 2009), histology, RT and CT dose parameters and BT details. Acute toxicities were recorded as per RTOG acute morbidity criteria. Disease free survival (DFS) was estimated using Kaplan-Meier method. Statistical analysis was done with SPSS (version 21.0) and p<0.05 was considered significant. Median age was 65 (range: 60-85 years). 26 patients had stage IIB; 69 and 5 patients respectively had stage IIIB and IVA disease. Median Karnofsky performance stage was 80 (range 70-90). All had squamous cell carcinoma histology except 4 patients (adenocarcinoma). Median external beam radiotherapy dose (EBRT) was 50 Gy (range: 20-50 Gy). 25 patients (25%) received concurrent chemotherapy with weekly Cisplatin 35-40 mg/m2; median 5 cycles (range: 2-6). Acute haematological and gastrointestinal toxicity grade ≥ 3 was seen in 8% and 11% patients respectively during EBRT. 71 patients received brachytherapy; 62 patients received high dose rate intracavitary brachytherapy (ICBT; 7 Gy x 3 fractions, weekly), 7 patients received pulsed dose rate ICBT (70 cGy×39 hourly pulses, total dose 27 Gy) and 2 patients received interstitial brachytherapy 10 Gy in 2 fractions, each one week apart. 29 patients did not receive brachytherapy. 10 patients (34.48%) defaulted for planned ICBT after EBRT; 8 patients (27.58%) refused ICBT; 6 patients (20.68%) could not receive it because of poor general condition and co-morbidities and 5 patients (17.24%) received EBRT boost in lieu of BT. Median follow up was 23.6 months (range: 4-46 months). 1 year and 2 year DFS for entire cohort was 74.9% and 68.9% respectively. 1 years and 2 year DFS rate for patients not receiving brachytherapy was 24% vs. 85.9% and 11.9% vs. 82.4% respectively (p<0.001). Age (> 70 vs. 60-69 years), use of concurrent chemotherapy and stage did not impact DFS significantly. Non-receipt of brachytherapy continued to be a predictor for worse survival on multivariate analysis (HR 0.056; 95% CI 0.0183 to 0.1723). Exclusion of BT from the radiotherapeutic management of E-CC adversely impacts survival. Reasons of non-receipt may help in understanding and increasing the compliance of patients for BT and hence improving survival." @default.
• W2758904077 created "2017-10-06" @default.
• W2758904077 creator A5017987361 @default.
• W2758904077 creator A5021886519 @default.
• W2758904077 creator A5043494941 @default.
• W2758904077 creator A5087422498 @default.
• W2758904077 date "2017-10-01" @default.
• W2758904077 modified "2023-10-16" @default.
• W2758904077 title "Impact of Brachytherapy use on Clinical Outcome of Elderly Patients of Carcinoma Cervix treated with Definitive Radiation Therapy" @default.
• W2758904077 doi "https://doi.org/10.1016/j.ijrobp.2017.06.1297" @default.
• W2758904077 hasPublicationYear "2017" @default.
• W2758904077 type Work @default.
• W2758904077 sameAs 2758904077 @default.
• W2758904077 citedByCount "0" @default.
• W2758904077 crossrefType "journal-article" @default.
• W2758904077 hasAuthorship W2758904077A5017987361 @default.
• W2758904077 hasAuthorship W2758904077A5021886519 @default.
• W2758904077 hasAuthorship W2758904077A5043494941 @default.
• W2758904077 hasAuthorship W2758904077A5087422498 @default.
• W2758904077 hasConcept C121608353 @default.
• W2758904077 hasConcept C126322002 @default.
• W2758904077 hasConcept C126838900 @default.
• W2758904077 hasConcept C141071460 @default.
• W2758904077 hasConcept C146357865 @default.
• W2758904077 hasConcept C151730666 @default.
• W2758904077 hasConcept C2775908122 @default.
• W2758904077 hasConcept C2776694085 @default.
• W2758904077 hasConcept C2777416452 @default.
• W2758904077 hasConcept C2777546739 @default.
• W2758904077 hasConcept C2777740455 @default.
• W2758904077 hasConcept C509974204 @default.
• W2758904077 hasConcept C71924100 @default.
• W2758904077 hasConcept C86803240 @default.
• W2758904077 hasConceptScore W2758904077C121608353 @default.
• W2758904077 hasConceptScore W2758904077C126322002 @default.
• W2758904077 hasConceptScore W2758904077C126838900 @default.
• W2758904077 hasConceptScore W2758904077C141071460 @default.
• W2758904077 hasConceptScore W2758904077C146357865 @default.
• W2758904077 hasConceptScore W2758904077C151730666 @default.
• W2758904077 hasConceptScore W2758904077C2775908122 @default.
• W2758904077 hasConceptScore W2758904077C2776694085 @default.
• W2758904077 hasConceptScore W2758904077C2777416452 @default.
• W2758904077 hasConceptScore W2758904077C2777546739 @default.
• W2758904077 hasConceptScore W2758904077C2777740455 @default.
• W2758904077 hasConceptScore W2758904077C509974204 @default.
• W2758904077 hasConceptScore W2758904077C71924100 @default.
• W2758904077 hasConceptScore W2758904077C86803240 @default.
• W2758904077 hasIssue "2" @default.
• W2758904077 hasLocation W27589040771 @default.
• W2758904077 hasOpenAccess W2758904077 @default.
• W2758904077 hasPrimaryLocation W27589040771 @default.
• W2758904077 hasRelatedWork W1981573615 @default.
• W2758904077 hasRelatedWork W2043597413 @default.
• W2758904077 hasRelatedWork W2161738555 @default.
• W2758904077 hasRelatedWork W2513916013 @default.
• W2758904077 hasRelatedWork W2617662644 @default.
• W2758904077 hasRelatedWork W2788839829 @default.
• W2758904077 hasRelatedWork W2966036943 @default.
• W2758904077 hasRelatedWork W3029213237 @default.
• W2758904077 hasRelatedWork W4206581437 @default.
• W2758904077 hasRelatedWork W4237106564 @default.
• W2758904077 hasVolume "99" @default.
• W2758904077 isParatext "false" @default.
• W2758904077 isRetracted "false" @default.
• W2758904077 magId "2758904077" @default.
• W2758904077 workType "article" @default.