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- W2758909599 abstract "Cellular BiophysicsCells are compartmentalized to allow distinct processes to occur in membrane-delimited organelles. But similar spatial restriction of cellular components in membrane-less intracellular assemblies or condensates also appears to occur—much like oil droplets in water. These compartments contribute to multiple biological processes and regulatory mechanisms. Shin and Brangwynne review the protein-protein and protein-RNA interactions that result in formation of these structures. They explain known and potential functions of such structures in a range of examples, from signaling and local control of biochemical reactants to spatial segregation. In disease, such aggregation may go awry and contribute to neurodegenerative syndromes associated with inappropriate protein aggregation.Science , this issue p. [eaaf4382][1] [1]: /lookup/doi/10.1126/science.aaf4382" @default.
- W2758909599 created "2017-10-06" @default.
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- W2758909599 date "2017-09-21" @default.
- W2758909599 modified "2023-09-26" @default.
- W2758909599 title "Phase separation and cellular organization" @default.
- W2758909599 doi "https://doi.org/10.1126/science.357.6357.1250-j" @default.
- W2758909599 hasPublicationYear "2017" @default.
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