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- W2758976297 abstract "Surveillance was recommended for patients after esophagectomy by National Comprehensive Cancer Network (NCCN) guidelines. The present study aimed to determine whether adjuvant treatment improved survival for stage node positive or stage III thoracic squamous cell carcinoma. A retrospective review of patients diagnosed as esophageal carcinoma in Chinese Academy of Medical Sciences, Cancer hospital between January 2004 and December 2011 was performed. A database compiling 975 patents with node positive or stage III thoracic esophageal carcinoma after surgery with or without postoperative radiation/chemoradiation was created. A 1:1 matched study group was created by Greedy method after propensity score matching (PSM) analysis. Survival curves were calculated by Kaplan-Meier method and compared with the log-rank test. Univariate and multivariate analyses were using the Cox proportional hazards regression model. 975 patients were enrolled into the study, 510 patients (52.3%) did not receive any postoperative treatment after surgery and 465 patients had either postoperative chemoradiation or radiotherapy, 331 patients had radiotherapy and 134 had postoperative chemoradiotherapy. Median follow-up was 69.2 months (95% CI 67.1-71.4 months). The 3-year, 5-year survival rates and median survival were 43.3%,32.8%, 28.9 months. DFS rates 37.7%, 31.7% and 22.5 months; and 52.3%, 40.3%, 41.8 months, respectively (P=0.000). After PSM, 222 well-balanced patients in each group. The 3-year, 5-year survival rates and median survival were 33.0%, 26.4%, 24.4 months; and 52.3%, 40.3%, 41.8 months, respectively (P=0.002). 33.0%, 26.4%, 24.4 months and 48.3%, 37.1%, 34.3months. N stage and adjuvant treatment are independent prognostic factors. Comparing with radiotherapy, postoperative chemoradiation did not improve DFS and OS. Adjuvant treatment could improve survival for patients with stage node positive or stage III thoracic squamous cell carcinoma. Further investigation is warranted." @default.
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- W2758976297 date "2017-10-01" @default.
- W2758976297 modified "2023-09-27" @default.
- W2758976297 title "A Prospensity-Score Analysis Comparing Long-Term Survival of Surgery Alone and Postoperative Radiation Therapy/Chemoradiation Therapy for Patients in Node Positive or Stage III Esophageal Squamous Cell Carcinoma after Esophagectomy" @default.
- W2758976297 doi "https://doi.org/10.1016/j.ijrobp.2017.06.1088" @default.
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