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• W2759091800 endingPage "2755" @default.
• W2759091800 startingPage "2746" @default.
• W2759091800 abstract "Anabaenopeptins are a diverse group of cyclic peptides, which contain an unusual ureido linkage. Namalides are shorter structural homologues of anabaenopeptins, which also contain an ureido linkage. The biosynthetic origins of namalides are unknown despite a strong resemblance to anabaenopeptins. Here, we show the cyanobacterium Nostoc sp. CENA543 strain producing new (nostamide B-E (2, 4, 5, and 6)) and known variants of anabaenopeptins (schizopeptin 791 (1) and anabaenopeptin 807 (3)). Surprisingly, Nostoc sp. CENA543 also produced namalide B (8) and the new namalides D (7), E (9), and F (10) in similar amounts to anabaenopeptins. Analysis of the complete Nostoc sp. CENA543 genome sequence indicates that both anabaenopeptins and namalides are produced by the same biosynthetic pathway through module skipping during biosynthesis. This unique process involves the skipping of two modules present in different nonribosomal peptide synthetases during the namalide biosynthesis. This skipping is an efficient mechanism since both anabaenopeptins and namalides are synthesized in similar amounts by Nostoc sp. CENA543. Consequently, gene skipping may be used to increase and possibly broaden the chemical diversity of related peptides produced by a single biosynthetic gene cluster. Genome mining demonstrated that the anabaenopeptin gene clusters are widespread in cyanobacteria and can also be found in tectomicrobia bacteria." @default.
• W2759091800 created "2017-10-06" @default.
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• W2759091800 date "2017-09-29" @default.
• W2759091800 modified "2023-10-15" @default.
• W2759091800 title "Simultaneous Production of Anabaenopeptins and Namalides by the Cyanobacterium <i>Nostoc</i> sp. CENA543" @default.
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• W2759091800 doi "https://doi.org/10.1021/acschembio.7b00570" @default.
• W2759091800 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28933529" @default.
• W2759091800 hasPublicationYear "2017" @default.
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