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- W2759092016 abstract "Abstract A technically simple procedure for direct C−H difluoromethylation of heteroaromatic compounds using off‐the‐shelf difluoroacetic acid as the difluoromethylating reagent has been developed. Mono‐difluoromethylation versus bis‐difluoromethylation is controlled as the result of the reaction temperature. The reactions described here enable access to the late‐stage C−H mono‐ and bis‐difluoromethylation for preparation of tool compounds for chemical biology and provide access to this hitherto untapped substituent for drug discovery." @default.
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- W2759092016 date "2017-10-11" @default.
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- W2759092016 title "Difluoroacetic Acid as a New Reagent for Direct C−H Difluoromethylation of Heteroaromatic Compounds" @default.
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- W2759092016 doi "https://doi.org/10.1002/chem.201704261" @default.
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