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- W2759097941 abstract "Hypophosphatasia (HPP) is a rare inherited skeletal disorder caused by mutations in the ALPL gene encoding tissue-nonspecific alkaline phosphatase, with early exfoliation of primary teeth due to disturbed formation of cementum often recognized as a major dental manifestation. However, reports regarding permanent teeth in HPP cases are scant. An 11-year-old boy diagnosed with childhood type HPP was referred to our hospital for exfoliation of the maxillary right central incisor. Micro-computed tomography findings of the affected tooth revealed external root resorption, enamel hypoplasia, thin dentin, and a wide pulp chamber, while disturbed cementum formation, enamel hypoplasia, dentin hypo-mineralization, and scant cementum around the enamel junction were observed by scanning electron microscopy. Permanent teeth may have a risk of early exfoliation as well as other structural abnormalities in HPP patients, thus longitudinal dental follow-up examinations of affected patients are required." @default.
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- W2759097941 date "2017-12-01" @default.
- W2759097941 modified "2023-10-06" @default.
- W2759097941 title "Early exfoliation of permanent tooth in patient with hypophosphatasia" @default.
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- W2759097941 doi "https://doi.org/10.1016/j.pdj.2017.08.005" @default.
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