Matches in SemOpenAlex for { <https://semopenalex.org/work/W2759158795> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W2759158795 endingPage "634" @default.
- W2759158795 startingPage "628" @default.
- W2759158795 abstract "Abstract Pro‐inflammatory cytokines are involved in the pathogenesis of inflammatory skin diseases attributable to activated neutrophils and macrophages. Myeloid‐derived suppressor cells (MDSCs) play an important role in the regulation of the immune response and possess strong immunosuppressive and anti‐inflammatory properties. Granulocyte and monocyte adsorption apheresis (GMA), an extracorporeal apheresis instrument featuring columns containing cellulose acetate (CA) beads, is designed to remove pathogenic myeloid lineage cells. The purpose of this study was to investigate the effects of GMA on cytokine production and MDSC induction. The serum level of various inflammatory cytokines and the incidence of MDSCs in peripheral blood before and after GMA treatment were recorded. Cytokines were assayed with the suspension‐array method in 38 patients. The incidence of MDSCs was analyzed by FACS in eight patients and the effect of GMA on in vitro MDSC induction was examined using a mini‐column system that mimics GMA. The serum level of IL‐2Rα ( P = 0.030), IL‐8 ( P = 0.018), and MIF ( P = 0.0002) was significantly decreased by GMA and the incidence of MDSCs was increased ( P = 0.030). With the mini‐column system, MDSCs were induced in the peripheral blood of five healthy volunteers; the in vitro induction was significantly inhibited by inactivation of the complement component iC3b. The clinical effectiveness of GMA may be attributable to the inhibition of pro‐inflammatory cytokines and the induction of anti‐inflammatory MDSCs by iC3b activation via the CA beads in the GMA column." @default.
- W2759158795 created "2017-10-06" @default.
- W2759158795 creator A5028104605 @default.
- W2759158795 creator A5073121970 @default.
- W2759158795 creator A5078816449 @default.
- W2759158795 date "2017-09-22" @default.
- W2759158795 modified "2023-10-16" @default.
- W2759158795 title "Inhibition of Inflammatory Cytokines and Induction of Myeloid-Derived Suppressor Cells by the Effects of Granulocyte and Monocyte Adsorption Apheresis" @default.
- W2759158795 cites W1483296685 @default.
- W2759158795 cites W1547538672 @default.
- W2759158795 cites W1581761477 @default.
- W2759158795 cites W1961906585 @default.
- W2759158795 cites W1972640453 @default.
- W2759158795 cites W1979039222 @default.
- W2759158795 cites W1984144734 @default.
- W2759158795 cites W1984802220 @default.
- W2759158795 cites W1989832114 @default.
- W2759158795 cites W2003492229 @default.
- W2759158795 cites W2004150448 @default.
- W2759158795 cites W2020846595 @default.
- W2759158795 cites W2021268612 @default.
- W2759158795 cites W2055522356 @default.
- W2759158795 cites W2059688175 @default.
- W2759158795 cites W2060429849 @default.
- W2759158795 cites W2073387523 @default.
- W2759158795 cites W2112240061 @default.
- W2759158795 cites W2112825482 @default.
- W2759158795 cites W2122163279 @default.
- W2759158795 cites W2126747080 @default.
- W2759158795 cites W2145122687 @default.
- W2759158795 cites W2150076493 @default.
- W2759158795 cites W2157852906 @default.
- W2759158795 cites W2170499630 @default.
- W2759158795 cites W2171435013 @default.
- W2759158795 cites W2432804423 @default.
- W2759158795 doi "https://doi.org/10.1111/1744-9987.12580" @default.
- W2759158795 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28941055" @default.
- W2759158795 hasPublicationYear "2017" @default.
- W2759158795 type Work @default.
- W2759158795 sameAs 2759158795 @default.
- W2759158795 citedByCount "5" @default.
- W2759158795 countsByYear W27591587952018 @default.
- W2759158795 countsByYear W27591587952020 @default.
- W2759158795 countsByYear W27591587952021 @default.
- W2759158795 countsByYear W27591587952023 @default.
- W2759158795 crossrefType "journal-article" @default.
- W2759158795 hasAuthorship W2759158795A5028104605 @default.
- W2759158795 hasAuthorship W2759158795A5073121970 @default.
- W2759158795 hasAuthorship W2759158795A5078816449 @default.
- W2759158795 hasConcept C121608353 @default.
- W2759158795 hasConcept C126322002 @default.
- W2759158795 hasConcept C179185449 @default.
- W2759158795 hasConcept C203014093 @default.
- W2759158795 hasConcept C2776738589 @default.
- W2759158795 hasConcept C2777983669 @default.
- W2759158795 hasConcept C2778690821 @default.
- W2759158795 hasConcept C2779282312 @default.
- W2759158795 hasConcept C2781184567 @default.
- W2759158795 hasConcept C55721878 @default.
- W2759158795 hasConcept C71924100 @default.
- W2759158795 hasConcept C8891405 @default.
- W2759158795 hasConcept C89560881 @default.
- W2759158795 hasConceptScore W2759158795C121608353 @default.
- W2759158795 hasConceptScore W2759158795C126322002 @default.
- W2759158795 hasConceptScore W2759158795C179185449 @default.
- W2759158795 hasConceptScore W2759158795C203014093 @default.
- W2759158795 hasConceptScore W2759158795C2776738589 @default.
- W2759158795 hasConceptScore W2759158795C2777983669 @default.
- W2759158795 hasConceptScore W2759158795C2778690821 @default.
- W2759158795 hasConceptScore W2759158795C2779282312 @default.
- W2759158795 hasConceptScore W2759158795C2781184567 @default.
- W2759158795 hasConceptScore W2759158795C55721878 @default.
- W2759158795 hasConceptScore W2759158795C71924100 @default.
- W2759158795 hasConceptScore W2759158795C8891405 @default.
- W2759158795 hasConceptScore W2759158795C89560881 @default.
- W2759158795 hasIssue "6" @default.
- W2759158795 hasLocation W27591587951 @default.
- W2759158795 hasLocation W27591587952 @default.
- W2759158795 hasOpenAccess W2759158795 @default.
- W2759158795 hasPrimaryLocation W27591587951 @default.
- W2759158795 hasRelatedWork W1547538672 @default.
- W2759158795 hasRelatedWork W2041497201 @default.
- W2759158795 hasRelatedWork W2058250272 @default.
- W2759158795 hasRelatedWork W2084179530 @default.
- W2759158795 hasRelatedWork W2109712624 @default.
- W2759158795 hasRelatedWork W2142604604 @default.
- W2759158795 hasRelatedWork W3195585944 @default.
- W2759158795 hasRelatedWork W4213262126 @default.
- W2759158795 hasRelatedWork W4247308142 @default.
- W2759158795 hasRelatedWork W176217205 @default.
- W2759158795 hasVolume "21" @default.
- W2759158795 isParatext "false" @default.
- W2759158795 isRetracted "false" @default.
- W2759158795 magId "2759158795" @default.
- W2759158795 workType "article" @default.