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• W2759174255 abstract "Prokaryotic AcrB-like proteins belong to a family of transporters of the RND superfamily, and as main contributing factor to multidrug resistance pose a tremendous threat to future human health. A unique feature of AcrB transporters is the presence of two separate domains responsible for carrying substrate and generating energy. Significant progress has been made in elucidating the three-dimensional structures of the homo-trimer complexes of AcrB-like transporters, and a three-step functional rotation was identified for this class of transporters. However, the detailed mechanisms for the transduction of the substrate binding signal, as well as the energy coupling processes between the functionally distinct domains remain to be established. Here, we propose a model for the interdomain communication in AcrB that explains how the substrate binding signal from the substrate-carrier domain triggers protonation in the transmembrane domain. Our model further provides a plausible mechanism that explains how protonation induces conformational changes in the substrate-carrier domain. We summarize the thermodynamic principles that govern the functional cycle of the AcrB trimer complex." @default.
• W2759174255 created "2017-10-06" @default.
• W2759174255 creator A5017353282 @default.
• W2759174255 creator A5078080058 @default.
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• W2759174255 date "2017-09-25" @default.
• W2759174255 modified "2023-10-10" @default.
• W2759174255 title "Energy coupling mechanisms of AcrB-like RND transporters" @default.
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• W2759174255 doi "https://doi.org/10.1007/s41048-017-0042-y" @default.
• W2759174255 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5719797" @default.
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